PMID- 2408592
OWN - NLM
STAT- MEDLINE
DCOM- 19850703
LR  - 20191022
IS  - 0167-4943 (Print)
IS  - 0167-4943 (Linking)
VI  - 4
IP  - 1
DP  - 1985 Apr
TI  - Dysdifferentiative nature of aging: age-dependent expression of mouse mammary 
      tumor virus and casein genes in brain and liver tissues of the C57BL/6J mouse 
      strain.
PG  - 43-51
AB  - Many aspects of the aging process could be the result of cells slowly drifting 
      away from their proper state of differentiation. This possibility has been 
      studied by searching for an age-dependent increase in the expression of specific 
      genes in tissues where expression of these genes would not normally be expected. 
      In these studies, cDNA probes of specific genes are used in a DNA X NA 
      hybridization assay to detect possible complementary RNA sequences in tissues of 
      different-aged animals. Using this technique in past experiments, a qualitative 
      increase in the RNA sequence complexity of mouse leukemia virus (MuLV) and a 
      quantitative increase in the amount of alpha- and beta-globin RNA were found with 
      increasing age in the brain and liver of the C57BL/6J mouse strain. We report 
      here a similar age-dependent qualitative increase in the RNA sequence complexity 
      for mouse mammary tumor virus (MMTV) but no quantitative or qualitative 
      age-dependent change in casein RNA sequences for the same tissues and mouse 
      strain.
FAU - Dean, R G
AU  - Dean RG
FAU - Socher, S H
AU  - Socher SH
FAU - Cutler, R G
AU  - Cutler RG
LA  - eng
GR  - CA-27293/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Arch Gerontol Geriatr
JT  - Archives of gerontology and geriatrics
JID - 8214379
RN  - 0 (Caseins)
RN  - 0 (RNA, Viral)
RN  - 63231-63-0 (RNA)
SB  - IM
MH  - *Aging
MH  - Animals
MH  - Brain Chemistry
MH  - Caseins/*genetics
MH  - Cell Differentiation
MH  - Gene Expression Regulation
MH  - *Genes, Viral
MH  - Liver/analysis
MH  - Mammary Tumor Virus, Mouse/*genetics
MH  - Mice
MH  - Mice, Inbred C57BL/*genetics
MH  - Nucleic Acid Hybridization
MH  - Oncogenes
MH  - RNA/analysis
MH  - RNA, Viral/analysis
EDAT- 1985/04/01 00:00
MHDA- 1985/04/01 00:01
CRDT- 1985/04/01 00:00
PHST- 1984/12/05 00:00 [received]
PHST- 1984/12/07 00:00 [accepted]
PHST- 1985/04/01 00:00 [pubmed]
PHST- 1985/04/01 00:01 [medline]
PHST- 1985/04/01 00:00 [entrez]
AID - 0167494385900172 [pii]
AID - 10.1016/0167-4943(85)90017-2 [doi]
PST - ppublish
SO  - Arch Gerontol Geriatr. 1985 Apr;4(1):43-51. doi: 10.1016/0167-4943(85)90017-2.