PMID- 24090383
OWN - NLM
STAT- MEDLINE
DCOM- 20131231
LR  - 20170310
IS  - 0022-9040 (Print)
IS  - 0022-9040 (Linking)
VI  - 53
IP  - 9
DP  - 2013
TI  - [Role of renal dysfunction and multifocal atherosclerosis in assessment of 
      prognosis of patients presenting with ST-elevation acute coronary syndrome].
PG  - 26-32
AB  - AIM: To assess incidence and severity of renal dysfunction as well as its 
      prognostic value in patients with ST elevation myocardial infarction (STEMI) and 
      multifocal atherosclerosis (MFA). MATERIAL AND METHODS: We enrolled in this study 
      529 patients with STEMI in whom we estimated creatinine clearance rate (eGFR) and 
      glomerular filtration rate (eCrCl) using Cockcroft-Gault equation and 
      Modification of Diet in Renal Disease (MDRD) formula, respectively. Duplex 
      ultrasonography of lower extremity and extracranial arteries was performed in 423 
      patients on day 5-10 of hospitalization. Signs of MFA were found in 95% of 
      patients. Hospital mortality was 10.9%. One year survival of 397 patients was 
      assessed by the telephone contacts. Thirty nine patients (9.8%) died. RESULTS: 
      GFR in 35.5% of patients was 30-60, and in 4.9% - less than 30 ml/min/1.73 m2. At 
      the same time 29.5% of patients had CCr 30 - 60, and 3.0% - less than 30 ml/min. 
      Progressive decreases of eCCr and eGFR were observed in patients with incipient 
      MFA (stenosis <30%); relationship between MFA and eGRF was more close. Presence 
      of renal dysfunction in patients with STEACS and MFA was associated elevation of 
      both hospital and 1 year mortality. CONCLUSION: Any manifestation of peripheral 
      atherosclerosis and impairment of renal function should be considered as 
      independent predictors of cardiovascular events in patients after STEMI.
FAU - Barbarash, O L
AU  - Barbarash OL
AD  - Research Institute for Complex Issues of Cardiovascular Diseases of SB of the 
      RAMS, Sosnovy boul. 6, 650002 Kemerovo, Russia.
FAU - Zykov, M V
AU  - Zykov MV
FAU - Bykova, I S
AU  - Bykova IS
FAU - Kashtalap, V V
AU  - Kashtalap VV
FAU - Karetnikova, V N
AU  - Karetnikova VN
FAU - Barbarash, L S
AU  - Barbarash LS
LA  - rus
PT  - English Abstract
PT  - Journal Article
PL  - Russia (Federation)
TA  - Kardiologiia
JT  - Kardiologiia
JID - 0376351
SB  - IM
MH  - Acute Coronary Syndrome/*complications/diagnosis/physiopathology
MH  - Electrocardiography/methods
MH  - Female
MH  - Glomerular Filtration Rate
MH  - Hospital Mortality
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Organ Dysfunction Scores
MH  - Peripheral Arterial Disease/*complications/diagnosis/physiopathology
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - ROC Curve
MH  - *Renal Insufficiency/diagnosis/etiology/physiopathology
MH  - Survival Analysis
MH  - Ultrasonography, Doppler, Color/methods
EDAT- 2013/10/05 06:00
MHDA- 2014/01/01 06:00
CRDT- 2013/10/05 06:00
PHST- 2013/10/05 06:00 [entrez]
PHST- 2013/10/05 06:00 [pubmed]
PHST- 2014/01/01 06:00 [medline]
PST - ppublish
SO  - Kardiologiia. 2013;53(9):26-32.