PMID- 24090445
OWN - NLM
STAT- MEDLINE
DCOM- 20140404
LR  - 20211021
IS  - 1471-2377 (Electronic)
IS  - 1471-2377 (Linking)
VI  - 13
DP  - 2013 Oct 3
TI  - Idiopathic acute transverse myelitis: outcome and conversion to multiple 
      sclerosis in a large series.
PG  - 135
LID - 10.1186/1471-2377-13-135 [doi]
AB  - BACKGROUND: In 2002, the Transverse Myelitis Consortium Working Group (TMCWG) 
      proposed the diagnostic criteria for idiopathic acute transverse myelitis (IATM) 
      to delimit and unify this group of patients. This study aimed to describe the 
      conversion rate to multiple sclerosis (MS) and variables associated with 
      conversion, and to analyze functional outcome and prognostic factors associated 
      with functional recovery in patients who fulfilled the current TMCWG criteria for 
      definite and possible IATM. METHODS: Eighty-seven patients diagnosed with IATM 
      between 1989 and 2011 were retrospectively reviewed. Two patients with positive 
      neuromyelitis optica IgG serum antibodies were excluded. Epidemiological, 
      clinical, laboratory, magnetic resonance imaging (MRI) data and outcome of 85 
      patients were analyzed. RESULTS: Eleven (13%) patients converted to MS after a 
      median follow-up of 2.9 years (interquartile range 1.0-4.8). Early-age onset of 
      symptoms was related to conversion to MS. Only 9.4% of patients with IATM were 
      unable to walk unassisted at the end of follow-up. Urinary sphincter dysfunction 
      (odds ratio [OR] 3.37, 95% confidence interval [CI] 1.04-10.92) and 
      longitudinally extensive transverse myelitis (LETM) on MRI (OR 12.34, 95% CI 
      3.38-45.00) were associated with a poorer outcome (Rankin >/= 2). CONCLUSIONS: At 
      least 13% of patients who fulfill the TMCWG criteria for definite and possible 
      IATM will convert to MS. Functional recovery in IATM is poorer in patients with 
      urinary sphincter dysfunction at admission or LETM on MRI.
FAU - Cobo Calvo, Alvaro
AU  - Cobo Calvo A
AD  - Multiple Sclerosis Unit, Neurology Department, Hospital Universitari de Bellvitge 
      - IDIBELL, Feixa Llarga s/n L'Hospitalet de Llobregat, Barcelona 08907, Spain. 
      acobo@bellvitgehospital.cat.
FAU - Mane Martinez, M Alba
AU  - Mane Martinez MA
FAU - Alentorn-Palau, Agusti
AU  - Alentorn-Palau A
FAU - Bruna Escuer, Jordi
AU  - Bruna Escuer J
FAU - Romero Pinel, Lucia
AU  - Romero Pinel L
FAU - Martinez-Yelamos, Sergio
AU  - Martinez-Yelamos S
LA  - eng
PT  - Journal Article
DEP - 20131003
PL  - England
TA  - BMC Neurol
JT  - BMC neurology
JID - 100968555
RN  - 0 (Autoantibodies)
RN  - 0 (Oligoclonal Bands)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Autoantibodies/blood
MH  - Chi-Square Distribution
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/*complications/*epidemiology
MH  - Myelitis, Transverse/diagnosis/*epidemiology/*etiology
MH  - Neuromyelitis Optica/blood
MH  - Oligoclonal Bands/blood/cerebrospinal fluid
MH  - Retrospective Studies
MH  - Statistics, Nonparametric
PMC - PMC3856522
EDAT- 2013/10/05 06:00
MHDA- 2014/04/05 06:00
PMCR- 2013/10/03
CRDT- 2013/10/05 06:00
PHST- 2013/03/26 00:00 [received]
PHST- 2013/09/24 00:00 [accepted]
PHST- 2013/10/05 06:00 [entrez]
PHST- 2013/10/05 06:00 [pubmed]
PHST- 2014/04/05 06:00 [medline]
PHST- 2013/10/03 00:00 [pmc-release]
AID - 1471-2377-13-135 [pii]
AID - 10.1186/1471-2377-13-135 [doi]
PST - epublish
SO  - BMC Neurol. 2013 Oct 3;13:135. doi: 10.1186/1471-2377-13-135.