PMID- 24091626
OWN - NLM
STAT- MEDLINE
DCOM- 20141002
LR  - 20211021
IS  - 1551-4005 (Electronic)
IS  - 1538-4101 (Print)
IS  - 1551-4005 (Linking)
VI  - 12
IP  - 22
DP  - 2013 Nov 15
TI  - Nature vs nurture: interplay between the genetic control of telomere length and 
      environmental factors.
PG  - 3465-70
LID - 10.4161/cc.26625 [doi]
AB  - Telomeres are nucleoprotein structures that cap the ends of the linear eukaryotic 
      chromosomes, thus protecting their stability and integrity. They play important 
      roles in DNA replication and repair and are central to our understanding of aging 
      and cancer development. In rapidly dividing cells, telomere length is maintained 
      by the activity of telomerase. About 400 TLM (telomere length maintenance) genes 
      have been identified in yeast, as participants of an intricate homeostasis 
      network that keeps telomere length constant. Two papers have recently shown that 
      despite this extremely complex control, telomere length can be manipulated by 
      external stimuli. These results have profound implications for our understanding 
      of cellular homeostatic systems in general and of telomere length maintenance in 
      particular. In addition, they point to the possibility of developing aging and 
      cancer therapies based on telomere length manipulation.
FAU - Harari, Yaniv
AU  - Harari Y
AD  - Department of Molecular Microbiology and Biotechnology; Tel Aviv University; 
      Ramat Aviv, Israel.
FAU - Romano, Gal-Hagit
AU  - Romano GH
FAU - Ungar, Lior
AU  - Ungar L
FAU - Kupiec, Martin
AU  - Kupiec M
LA  - eng
PT  - Comment
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130926
PL  - United States
TA  - Cell Cycle
JT  - Cell cycle (Georgetown, Tex.)
JID - 101137841
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Saccharomyces cerevisiae Proteins)
RN  - 0 (Telomere-Binding Proteins)
RN  - 0 (Transcription Factors)
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
CON - Curr Biol. 2011 Dec 20;21(24):2115-20. PMID: 22169538
CON - PLoS Genet. 2013;9(9):e1003721. PMID: 24039592
MH  - DNA-Binding Proteins/*metabolism
MH  - Humans
MH  - Saccharomyces cerevisiae/*metabolism
MH  - Saccharomyces cerevisiae Proteins/*genetics/*metabolism
MH  - Sirolimus/*pharmacology
MH  - *Stress, Physiological
MH  - Telomere/*genetics/*metabolism
MH  - Telomere Homeostasis/*genetics
MH  - *Telomere Shortening
MH  - Telomere-Binding Proteins/*genetics
MH  - Transcription Factors/*genetics/*metabolism
PMC - PMC3906331
OTO - NOTNLM
OT  - aging
OT  - cancer
OT  - genome stability
OT  - homeostasis
OT  - telomeres
OT  - yeast
EDAT- 2013/10/05 06:00
MHDA- 2014/10/03 06:00
PMCR- 2014/11/15
CRDT- 2013/10/05 06:00
PHST- 2013/10/05 06:00 [entrez]
PHST- 2013/10/05 06:00 [pubmed]
PHST- 2014/10/03 06:00 [medline]
PHST- 2014/11/15 00:00 [pmc-release]
AID - 26625 [pii]
AID - 2013CC5294R [pii]
AID - 10.4161/cc.26625 [doi]
PST - ppublish
SO  - Cell Cycle. 2013 Nov 15;12(22):3465-70. doi: 10.4161/cc.26625. Epub 2013 Sep 26.