PMID- 24092248
OWN - NLM
STAT- MEDLINE
DCOM- 20140617
LR  - 20131115
IS  - 1522-9645 (Electronic)
IS  - 0195-668X (Linking)
VI  - 34
IP  - 43
DP  - 2013 Nov
TI  - Trends in the outcomes of percutaneous coronary intervention with the routine 
      incorporation of fractional flow reserve in real practice.
PG  - 3353-61
LID - 10.1093/eurheartj/eht404 [doi]
AB  - AIMS: We evaluated the impact of the routine use of fractional flow reserve (FFR) 
      on the practice and outcomes of percutaneous coronary intervention (PCI). METHODS 
      AND RESULTS: Between January 2008 and December 2011, the rate of FFR use during 
      PCI increased from 1.9 to 50.7% after the introduction of routine FFR use (P < 
      0.001). A total of 5097 patients (2699 patients before and 2398 after the routine 
      use of FFR) underwent PCI at an academic hospital in Korea; of those, stent 
      implantation was deferred in 475 patients. We used propensity score (PS) matching 
      to compare the rates of the primary endpoint [death, myocardial infarction (MI), 
      or repeat revascularization] at 1 year the cohort before and after the routine 
      use of FFR. In the PS-matched cohort (2178 pairs), the median number of lesions 
      per patient was 2 [inter-quartile range (IQR) 1-2] before vs. 2 (IQR 1-2) after 
      the routine FFR use (P = 0.68); the median number of stents implanted per patient 
      was 2 (IQR 1-3) vs. 1 (IQR 1-2), respectively (P < 0.001). The rates of the 
      primary endpoint at 1 year was significantly lower in patients after the routine 
      FFR use vs. patients before the routine use of FFR (hazard ratio 0.55; 95% 
      confidence interval 0.43-0.70; P < 0.001). This was primarily due to a reduction 
      in peri-procedural MI and repeat revascularization. CONCLUSION: Routine 
      measurement of FFR in daily practice appeared to be associated with less use of 
      stents and an improvement in clinical outcomes. CLINICALTRIALSGOV NUMBER: NCT 
      01788592.
FAU - Park, Seung-Jung
AU  - Park SJ
AD  - Heart Institute, Center for Medical Research and Information, Asan Medical 
      Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong, Songpa-gu, 
      Seoul 138-736, South Korea.
FAU - Ahn, Jung-Min
AU  - Ahn JM
FAU - Park, Gyung-Min
AU  - Park GM
FAU - Cho, Young-Rak
AU  - Cho YR
FAU - Lee, Jong-Young
AU  - Lee JY
FAU - Kim, Won-Jang
AU  - Kim WJ
FAU - Han, Seungbong
AU  - Han S
FAU - Kang, Soo-Jin
AU  - Kang SJ
FAU - Park, Duk-Woo
AU  - Park DW
FAU - Lee, Seung-Whan
AU  - Lee SW
FAU - Kim, Young-Hak
AU  - Kim YH
FAU - Lee, Cheol Whan
AU  - Lee CW
FAU - Mintz, Gary S
AU  - Mintz GS
FAU - Park, Seong-Wook
AU  - Park SW
LA  - eng
SI  - ClinicalTrials.gov/NCT01788592
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131002
PL  - England
TA  - Eur Heart J
JT  - European heart journal
JID - 8006263
SB  - IM
MH  - Female
MH  - Fractional Flow Reserve, Myocardial/physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*therapy
MH  - Percutaneous Coronary Intervention/*trends
MH  - Propensity Score
MH  - Prospective Studies
MH  - Stents/statistics & numerical data
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Coronary Disease
OT  - Fractional Flow Reserve
OT  - Prognosis
OT  - Stents
EDAT- 2013/10/05 06:00
MHDA- 2014/06/18 06:00
CRDT- 2013/10/05 06:00
PHST- 2013/10/05 06:00 [entrez]
PHST- 2013/10/05 06:00 [pubmed]
PHST- 2014/06/18 06:00 [medline]
AID - eht404 [pii]
AID - 10.1093/eurheartj/eht404 [doi]
PST - ppublish
SO  - Eur Heart J. 2013 Nov;34(43):3353-61. doi: 10.1093/eurheartj/eht404. Epub 2013 
      Oct 2.