PMID- 24092446
OWN - NLM
STAT- MEDLINE
DCOM- 20140701
LR  - 20131114
IS  - 1755-3245 (Electronic)
IS  - 0008-6363 (Linking)
VI  - 100
IP  - 3
DP  - 2013 Dec 1
TI  - Physical training and hypertension have opposite effects on endothelial 
      brain-derived neurotrophic factor expression.
PG  - 374-82
LID - 10.1093/cvr/cvt219 [doi]
AB  - AIMS: Changes in circulating brain-derived neurotrophic factor (BDNF) levels were 
      reported in patients with or at risk for cardiovascular diseases associated with 
      endothelial dysfunction, suggesting a link between BDNF and endothelial 
      functionality. However, little is known on cardiovascular BDNF. Our aim was to 
      investigate levels/localization, function, and relevance of cardiovascular BDNF. 
      METHODS AND RESULTS: BDNF levels (western blotting) and localization 
      (immunostaining) were assessed in the heart and aorta from rats with impaired 
      (spontaneously hypertensive rats [SHR]), normal (Wistar Kyoto rats [WKY]), and 
      improved (SHR and WKY subjected to physical training) endothelial function. BDNF 
      levels were also measured in cultured endothelial cells (CECs) subjected to low 
      and high shear stress. The cardiovascular effects of BDNF were investigated in 
      isolated aortic rings and hearts. The results showed high BDNF levels in the 
      heart and aorta, the expression being prominent in endothelial cells as compared 
      with other cell types. Exogenous BDNF vasodilated aortic rings but changed 
      neither coronary flow nor cardiac contractility. Hypertension was associated with 
      decreased expression of BDNF in the endothelium, whereas physical training led to 
      endothelial BDNF up-regulation not only in WKY but also in SHR. Exposure of CECs 
      to high shear stress stimulated BDNF production and secretion. CONCLUSION: 
      Cardiovascular BDNF is mainly localized within endothelial cells in which its 
      expression is dependent on endothelial function. These results open new 
      perspectives on the role of endothelial BDNF in cardiovascular health.
FAU - Prigent-Tessier, Anne
AU  - Prigent-Tessier A
AD  - INSERM U1093 Cognition, Action et Plasticite Sensorimotrice, Universite de 
      Bourgogne, Dijon, France.
FAU - Quirie, Aurore
AU  - Quirie A
FAU - Maguin-Gate, Katy
AU  - Maguin-Gate K
FAU - Szostak, Justyna
AU  - Szostak J
FAU - Mossiat, Claude
AU  - Mossiat C
FAU - Nappey, Maude
AU  - Nappey M
FAU - Devaux, Sylvie
AU  - Devaux S
FAU - Marie, Christine
AU  - Marie C
FAU - Demougeot, Celine
AU  - Demougeot C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131003
PL  - England
TA  - Cardiovasc Res
JT  - Cardiovascular research
JID - 0077427
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Aorta, Thoracic/*metabolism/physiopathology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cells, Cultured
MH  - Coronary Circulation
MH  - Coronary Vessels/*metabolism/physiopathology
MH  - Disease Models, Animal
MH  - Endothelial Cells/*metabolism
MH  - Hypertension/*metabolism/physiopathology
MH  - Male
MH  - Myocardial Contraction
MH  - *Physical Conditioning, Animal
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - Regional Blood Flow
MH  - Stress, Mechanical
MH  - Time Factors
MH  - Vasodilation
MH  - Ventricular Function, Left
MH  - Ventricular Pressure
OTO - NOTNLM
OT  - BDNF
OT  - Endothelium
OT  - Hypertension
OT  - Physical training
OT  - Shear stress
EDAT- 2013/10/05 06:00
MHDA- 2014/07/02 06:00
CRDT- 2013/10/05 06:00
PHST- 2013/10/05 06:00 [entrez]
PHST- 2013/10/05 06:00 [pubmed]
PHST- 2014/07/02 06:00 [medline]
AID - cvt219 [pii]
AID - 10.1093/cvr/cvt219 [doi]
PST - ppublish
SO  - Cardiovasc Res. 2013 Dec 1;100(3):374-82. doi: 10.1093/cvr/cvt219. Epub 2013 Oct 
      3.