PMID- 24095719
OWN - NLM
STAT- MEDLINE
DCOM- 20131217
LR  - 20131025
IS  - 1769-6917 (Electronic)
IS  - 0007-4551 (Linking)
VI  - 100
IP  - 10
DP  - 2013 Oct
TI  - [Comparative cost analysis of molecular biology methods in the diagnosis of 
      sarcomas].
PG  - 963-71
LID - 10.1684/bdc.2013.1822 [doi]
AB  - Sarcomas represent a complex and heterogeneous group of rare malignant tumors and 
      their correct diagnosis is often difficult. Recent molecular biological 
      techniques have been of great diagnostic use and there is a need to assess the 
      cost of these procedures in routine clinical practice. Using prospective and 
      observational data from eight molecular biology laboratories in France, we used 
      "microcosting" method to assess the cost of molecular biological techniques in 
      the diagnosis of five types of sarcoma. The mean cost of fluorescence in situ 
      hybridization (FISH) was 318 euro (273-393) per sample; mean reverse transcription 
      polymerase chain reaction (RT-PCR) cost ranged from 300 euro (229-481) per 
      formalin-fixed, paraffin-embedded specimen to 258 euro (213-339) per frozen 
      specimen; mean quantitative polymerase chain reaction (Q-PCR) cost was 184 euro 
      (112-229) and mean CGH-array cost was 332 euro (329-335). The cost of these recently 
      implemented techniques varied according to the type of sarcoma; the method of 
      tissue collection and local organizational factors including the level of local 
      expertise and investment. The cost of molecular diagnostic techniques needs to be 
      balanced against their respective performance.
FAU - Baffert, Sandrine
AU  - Baffert S
AD  - Institut Curie, departement de sante publique, 26, rue d'Ulm, 75005 Paris, 
      France.
FAU - Italiano, Antoine
AU  - Italiano A
FAU - Pierron, Gaelle
AU  - Pierron G
FAU - Traore, Marie-Angele
AU  - Traore MA
FAU - Rapp, Jocelyn
AU  - Rapp J
FAU - Escande, Fabienne
AU  - Escande F
FAU - Ghnassia, Jean-Pierre
AU  - Ghnassia JP
FAU - Terrier, Philippe
AU  - Terrier P
FAU - Voegeli, Anne-Claire
AU  - Voegeli AC
FAU - Ranchere-Vince, Dominique
AU  - Ranchere-Vince D
FAU - Coindre, Jean-Michel
AU  - Coindre JM
FAU - Pedeutour, Florence
AU  - Pedeutour F
LA  - fre
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
TT  - Analyse comparative des couts de techniques de biologie moleculaire dans le 
      diagnostic de sarcomes.
PL  - France
TA  - Bull Cancer
JT  - Bulletin du cancer
JID - 0072416
SB  - IM
MH  - Comparative Genomic Hybridization/*economics
MH  - Costs and Cost Analysis
MH  - Dermatofibrosarcoma/diagnosis/genetics
MH  - France
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*economics
MH  - Liposarcoma/diagnosis/genetics
MH  - Memory, Episodic
MH  - Paraffin Embedding/*economics
MH  - Rare Diseases/*diagnosis/genetics
MH  - Real-Time Polymerase Chain Reaction/*economics
MH  - Reverse Transcriptase Polymerase Chain Reaction/*economics
MH  - Rhabdomyosarcoma, Alveolar/diagnosis/genetics
MH  - Sarcoma/*diagnosis/genetics
MH  - Sarcoma, Ewing/diagnosis/genetics
MH  - Sarcoma, Synovial/diagnosis/genetics
MH  - Skin Neoplasms/diagnosis/genetics
OTO - NOTNLM
OT  - cost
OT  - methods for diagnosis
OT  - microcosting
OT  - molecular biology
OT  - sarcomas
EDAT- 2013/10/08 06:00
MHDA- 2013/12/18 06:00
CRDT- 2013/10/08 06:00
PHST- 2013/10/08 06:00 [entrez]
PHST- 2013/10/08 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
AID - S0007-4551(15)30204-6 [pii]
AID - 10.1684/bdc.2013.1822 [doi]
PST - ppublish
SO  - Bull Cancer. 2013 Oct;100(10):963-71. doi: 10.1684/bdc.2013.1822.