PMID- 24095837
OWN - NLM
STAT- MEDLINE
DCOM- 20140730
LR  - 20220321
IS  - 1522-9653 (Electronic)
IS  - 1063-4584 (Linking)
VI  - 21
IP  - 12
DP  - 2013 Dec
TI  - Total knee replacement; minimal clinically important differences and responders.
PG  - 2006-12
LID - S1063-4584(13)00967-9 [pii]
LID - 10.1016/j.joca.2013.09.009 [doi]
AB  - OBJECTIVE: To provide new data on minimally clinical important difference (MCID) 
      and percentages of responders on pain and functional dimensions of Western 
      Ontario and McMaster Osteoarthritis Index (WOMAC) in patients who have undergone 
      total knee replacement (TKR). METHODS: 1-year prospective multicentre study with 
      two different cohorts. Consecutive patients on the waiting list were recruited. 
      There were 415 and 497 patients included. Pain and function were collected by the 
      reverse scoring option of the WOMAC (0-100, worst to best). Transition items 
      (five point scale) were collected at 1-year and MCID was calculated through mean 
      change in patients somewhat better, Receiver Operating Characteristic (ROC) and 
      two other questions about satisfaction. Analysis was performed in the whole 
      sample and by tertiles of baseline severity. Likewise were calculated the 
      percentages of patients who attained cut-off values. RESULTS: Global MCID for 
      pain were about 30 in both cohorts and 32 for. By ROC these values were about 20 
      and 24 respectively. According to the other two transitional questions these 
      values were for pain 27 and 20 for function. By tertiles the worst the baseline 
      score the higher the cut-off values. Percentage of responders does not change 
      when comparing responders to the global MCID with their own tertile MCID and were 
      about 61% for pain and 50% for function. CONCLUSION: Due to the wide variations, 
      MCID estimates should be calculated and used according to the baseline severity 
      score.
CI  - Copyright (c) 2013 Osteoarthritis Research Society International. Published by 
      Elsevier Ltd. All rights reserved.
FAU - Escobar, A
AU  - Escobar A
AD  - Research Unit, Hospital Universitario Basurto, Avda. Montevideo 18, 48013 Bilbao, 
      Spain. Electronic address: antonio.escobarmartinez@osakidetza.net.
FAU - Garcia Perez, L
AU  - Garcia Perez L
FAU - Herrera-Espineira, C
AU  - Herrera-Espineira C
FAU - Aizpuru, F
AU  - Aizpuru F
FAU - Sarasqueta, C
AU  - Sarasqueta C
FAU - Gonzalez Saenz de Tejada, M
AU  - Gonzalez Saenz de Tejada M
FAU - Quintana, J M
AU  - Quintana JM
FAU - Bilbao, A
AU  - Bilbao A
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20131002
PL  - England
TA  - Osteoarthritis Cartilage
JT  - Osteoarthritis and cartilage
JID - 9305697
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Arthroplasty, Replacement, Knee
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Osteoarthritis, Knee/*surgery
MH  - Pain Measurement
MH  - Patient Satisfaction
MH  - Prospective Studies
MH  - *Quality of Life
MH  - *Recovery of Function
MH  - Severity of Illness Index
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
OTO - NOTNLM
OT  - MCID
OT  - Responders
OT  - Total knee replacement
EDAT- 2013/10/08 06:00
MHDA- 2014/07/31 06:00
CRDT- 2013/10/08 06:00
PHST- 2013/05/22 00:00 [received]
PHST- 2013/09/20 00:00 [revised]
PHST- 2013/09/24 00:00 [accepted]
PHST- 2013/10/08 06:00 [entrez]
PHST- 2013/10/08 06:00 [pubmed]
PHST- 2014/07/31 06:00 [medline]
AID - S1063-4584(13)00967-9 [pii]
AID - 10.1016/j.joca.2013.09.009 [doi]
PST - ppublish
SO  - Osteoarthritis Cartilage. 2013 Dec;21(12):2006-12. doi: 
      10.1016/j.joca.2013.09.009. Epub 2013 Oct 2.