PMID- 24096214
OWN - NLM
STAT- MEDLINE
DCOM- 20140620
LR  - 20220330
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 1539
DP  - 2013 Nov 20
TI  - Depression, anxiety-like behavior and memory impairment are associated with 
      increased oxidative stress and inflammation in a rat model of social stress.
PG  - 73-86
LID - S0006-8993(13)01307-3 [pii]
LID - 10.1016/j.brainres.2013.09.033 [doi]
AB  - In the present study, we have examined the behavioral and biochemical effect of 
      induction of psychological stress using a modified version of the 
      resident-intruder model for social stress (social defeat). At the end of the 
      social defeat protocol, body weights, food and water intake were recorded, 
      depression and anxiety-like behaviors as well as memory function was examined. 
      Biochemical analysis including oxidative stress measurement, inflammatory markers 
      and other molecular parameters, critical to behavioral effects were examined. We 
      observed a significant decrease in the body weight in the socially defeated rats 
      as compared to the controls. Furthermore, social defeat increased anxiety-like 
      behavior and caused memory impairment in rats (P<0.05). Socially defeated rats 
      made significantly more errors in long term memory tests (P<0.05) as compared to 
      control rats. Furthermore, brain extracellular signal-regulated kinase-1/2 
      (ERK1/2), and an inflammatory marker, interleukin (IL)-6 were activated (P<0.05), 
      while the protein levels of glyoxalase (GLO)-1, glutathione reductase (GSR)-1, 
      calcium/calmodulin-dependent protein kinase type (CAMK)-IV, 
      cAMP-response-element-binding protein (CREB) and brain-derived neurotrophic 
      factor (BDNF) were significantly less (P<0.05) in the hippocampus, but not in the 
      prefrontal cortex and amygdala of socially defeated rats, when compared to 
      control rats. We suggest that social defeat stress alters ERK1/2, IL-6, GLO1, 
      GSR1, CAMKIV, CREB, and BDNF levels in specific brain areas, leading to oxidative 
      stress-induced anxiety-depression-like behaviors and as well as memory impairment 
      in rats.
CI  - (c) 2013 Published by Elsevier B.V.
FAU - Patki, Gaurav
AU  - Patki G
AD  - Department of Pharmacological and Pharmaceutical Sciences, University of Houston, 
      Houston, TX 77204, USA.
FAU - Solanki, Naimesh
AU  - Solanki N
FAU - Atrooz, Fatin
AU  - Atrooz F
FAU - Allam, Farida
AU  - Allam F
FAU - Salim, Samina
AU  - Salim S
LA  - eng
GR  - R15 MH093918/MH/NIMH NIH HHS/United States
GR  - R15G103327/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20131003
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
SB  - IM
MH  - Animals
MH  - Anxiety/metabolism
MH  - Brain/*metabolism
MH  - Depression/metabolism
MH  - Disease Models, Animal
MH  - Inflammation
MH  - Male
MH  - Memory Disorders/metabolism
MH  - *Oxidative Stress
MH  - Rats
MH  - Rats, Long-Evans
MH  - Rats, Sprague-Dawley
MH  - Social Dominance
MH  - Stress, Psychological/*metabolism
PMC - PMC4316676
MID - NIHMS533691
OTO - NOTNLM
OT  - Anxiety
OT  - BDNF
OT  - CAMKIV
OT  - ECL
OT  - ERK1/2
OT  - GLO-1
OT  - GSR
OT  - LE
OT  - Learning and memory and social defeat
OT  - Long-Evans
OT  - Oxidative stress: depression
OT  - P-CREB
OT  - PVDF
OT  - RAWM
OT  - SD
OT  - SDS-PAGE
OT  - SOD
OT  - SS
OT  - Sprague Dawley
OT  - T-CREB
OT  - brain derived neurotrophic factor
OT  - calcium/calmodulin-dependent protein kinase type IV
OT  - enhanced chemiluminescence
OT  - extracellular signal-regulated kinase-1/2
OT  - glutathione reductase-1
OT  - glyoxalase-1
OT  - phospho-cAMP response element-binding protein
OT  - polyvinyledene difluoride
OT  - radial arm water maze
OT  - social stressed
OT  - sodium dodecyl sulfate polyacrylamide gel electrophoresis
OT  - superoxide dismutase
OT  - total-cAMP response element-binding protein
COIS- Author disclosure: The authors declare no conflict of interest.
EDAT- 2013/10/08 06:00
MHDA- 2014/06/21 06:00
PMCR- 2015/02/04
CRDT- 2013/10/08 06:00
PHST- 2013/05/28 00:00 [received]
PHST- 2013/09/20 00:00 [revised]
PHST- 2013/09/22 00:00 [accepted]
PHST- 2013/10/08 06:00 [entrez]
PHST- 2013/10/08 06:00 [pubmed]
PHST- 2014/06/21 06:00 [medline]
PHST- 2015/02/04 00:00 [pmc-release]
AID - S0006-8993(13)01307-3 [pii]
AID - 10.1016/j.brainres.2013.09.033 [doi]
PST - ppublish
SO  - Brain Res. 2013 Nov 20;1539:73-86. doi: 10.1016/j.brainres.2013.09.033. Epub 2013 
      Oct 3.