PMID- 24097067
OWN - NLM
STAT- MEDLINE
DCOM- 20140108
LR  - 20220408
IS  - 1546-1718 (Electronic)
IS  - 1061-4036 (Print)
IS  - 1061-4036 (Linking)
VI  - 45
IP  - 11
DP  - 2013 Nov
TI  - Variants at multiple loci implicated in both innate and adaptive immune responses 
      are associated with Sjogren's syndrome.
PG  - 1284-92
LID - 10.1038/ng.2792 [doi]
AB  - Sjogren's syndrome is a common autoimmune disease (affecting  approximately 0.7% of European 
      Americans) that typically presents as keratoconjunctivitis sicca and xerostomia. 
      Here we report results of a large-scale association study of Sjogren's syndrome. 
      In addition to strong association within the human leukocyte antigen (HLA) region 
      at 6p21 (Pmeta = 7.65 x 10(-114)), we establish associations with IRF5-TNPO3 
      (Pmeta = 2.73 x 10(-19)), STAT4 (Pmeta = 6.80 x 10(-15)), IL12A (Pmeta = 1.17 x 
      10(-10)), FAM167A-BLK (Pmeta = 4.97 x 10(-10)), DDX6-CXCR5 (Pmeta = 1.10 x 
      10(-8)) and TNIP1 (Pmeta = 3.30 x 10(-8)). We also observed suggestive 
      associations (Pmeta < 5 x 10(-5)) with variants in 29 other regions, including 
      TNFAIP3, PTTG1, PRDM1, DGKQ, FCGR2A, IRAK1BP1, ITSN2 and PHIP, among others. 
      These results highlight the importance of genes that are involved in both innate 
      and adaptive immunity in Sjogren's syndrome.
FAU - Lessard, Christopher J
AU  - Lessard CJ
AD  - 1] Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research 
      Foundation, Oklahoma City, Oklahoma, USA. [2] Department of Pathology, University 
      of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
FAU - Li, He
AU  - Li H
FAU - Adrianto, Indra
AU  - Adrianto I
FAU - Ice, John A
AU  - Ice JA
FAU - Rasmussen, Astrid
AU  - Rasmussen A
FAU - Grundahl, Kiely M
AU  - Grundahl KM
FAU - Kelly, Jennifer A
AU  - Kelly JA
FAU - Dozmorov, Mikhail G
AU  - Dozmorov MG
FAU - Miceli-Richard, Corinne
AU  - Miceli-Richard C
FAU - Bowman, Simon
AU  - Bowman S
FAU - Lester, Sue
AU  - Lester S
FAU - Eriksson, Per
AU  - Eriksson P
FAU - Eloranta, Maija-Leena
AU  - Eloranta ML
FAU - Brun, Johan G
AU  - Brun JG
FAU - Goransson, Lasse G
AU  - Goransson LG
FAU - Harboe, Erna
AU  - Harboe E
FAU - Guthridge, Joel M
AU  - Guthridge JM
FAU - Kaufman, Kenneth M
AU  - Kaufman KM
FAU - Kvarnstrom, Marika
AU  - Kvarnstrom M
FAU - Jazebi, Helmi
AU  - Jazebi H
FAU - Cunninghame Graham, Deborah S
AU  - Cunninghame Graham DS
FAU - Grandits, Martha E
AU  - Grandits ME
FAU - Nazmul-Hossain, Abu N M
AU  - Nazmul-Hossain AN
FAU - Patel, Ketan
AU  - Patel K
FAU - Adler, Adam J
AU  - Adler AJ
FAU - Maier-Moore, Jacen S
AU  - Maier-Moore JS
FAU - Farris, A Darise
AU  - Farris AD
FAU - Brennan, Michael T
AU  - Brennan MT
FAU - Lessard, James A
AU  - Lessard JA
FAU - Chodosh, James
AU  - Chodosh J
FAU - Gopalakrishnan, Rajaram
AU  - Gopalakrishnan R
FAU - Hefner, Kimberly S
AU  - Hefner KS
FAU - Houston, Glen D
AU  - Houston GD
FAU - Huang, Andrew J W
AU  - Huang AJ
FAU - Hughes, Pamela J
AU  - Hughes PJ
FAU - Lewis, David M
AU  - Lewis DM
FAU - Radfar, Lida
AU  - Radfar L
FAU - Rohrer, Michael D
AU  - Rohrer MD
FAU - Stone, Donald U
AU  - Stone DU
FAU - Wren, Jonathan D
AU  - Wren JD
FAU - Vyse, Timothy J
AU  - Vyse TJ
FAU - Gaffney, Patrick M
AU  - Gaffney PM
FAU - James, Judith A
AU  - James JA
FAU - Omdal, Roald
AU  - Omdal R
FAU - Wahren-Herlenius, Marie
AU  - Wahren-Herlenius M
FAU - Illei, Gabor G
AU  - Illei GG
FAU - Witte, Torsten
AU  - Witte T
FAU - Jonsson, Roland
AU  - Jonsson R
FAU - Rischmueller, Maureen
AU  - Rischmueller M
FAU - Ronnblom, Lars
AU  - Ronnblom L
FAU - Nordmark, Gunnel
AU  - Nordmark G
FAU - Ng, Wan-Fai
AU  - Ng WF
CN  - UK Primary Sjogren's Syndrome Registry
FAU - Mariette, Xavier
AU  - Mariette X
FAU - Anaya, Juan-Manuel
AU  - Anaya JM
FAU - Rhodus, Nelson L
AU  - Rhodus NL
FAU - Segal, Barbara M
AU  - Segal BM
FAU - Scofield, R Hal
AU  - Scofield RH
FAU - Montgomery, Courtney G
AU  - Montgomery CG
FAU - Harley, John B
AU  - Harley JB
FAU - Sivils, Kathy L
AU  - Sivils KL
LA  - eng
GR  - R01 DE015223/DE/NIDCR NIH HHS/United States
GR  - 7S10 RR027190-02/RR/NCRR NIH HHS/United States
GR  - G0800629/MRC_/Medical Research Council/United Kingdom
GR  - U01 AI101934/AI/NIAID NIH HHS/United States
GR  - 5P30 GM103510/GM/NIGMS NIH HHS/United States
GR  - 5RC2 AR058959/AR/NIAMS NIH HHS/United States
GR  - 8P20 GM103456/GM/NIGMS NIH HHS/United States
GR  - 5P01 AR049084-10/AR/NIAMS NIH HHS/United States
GR  - P20 GM103636/GM/NIGMS NIH HHS/United States
GR  - P01 AR049084/AR/NIAMS NIH HHS/United States
GR  - R01 DE018209/DE/NIDCR NIH HHS/United States
GR  - 5P01 AI083194-03/AI/NIAID NIH HHS/United States
GR  - 5R01 DE015223/DE/NIDCR NIH HHS/United States
GR  - U19 AI082714/AI/NIAID NIH HHS/United States
GR  - P30 GM103510/GM/NIGMS NIH HHS/United States
GR  - P20 GM103456/GM/NIGMS NIH HHS/United States
GR  - P50 AR0608040/AR/NIAMS NIH HHS/United States
GR  - MR/J002720/1/MRC_/Medical Research Council/United Kingdom
GR  - RC1 AR058554/AR/NIAMS NIH HHS/United States
GR  - P30 AR053483/AR/NIAMS NIH HHS/United States
GR  - 1U01 AI101934/AI/NIAID NIH HHS/United States
GR  - P50 AR060804/AR/NIAMS NIH HHS/United States
GR  - 5R01 DE018209/DE/NIDCR NIH HHS/United States
GR  - 1R01 DE018209-02/DE/NIDCR NIH HHS/United States
GR  - 5U19 AI082714/AI/NIAID NIH HHS/United States
GR  - R37 AI024717/AI/NIAID NIH HHS/United States
GR  - S10 RR027190/RR/NCRR NIH HHS/United States
GR  - ImNIH/Intramural NIH HHS/United States
GR  - UK G0800629/MRC_/Medical Research Council/United Kingdom
GR  - 5P30 AR053483/AR/NIAMS NIH HHS/United States
GR  - I01 BX001834/BX/BLRD VA/United States
GR  - RC2 AR058959/AR/NIAMS NIH HHS/United States
GR  - P01 AI083194/AI/NIAID NIH HHS/United States
GR  - 5R37 AI024717-25/AI/NIAID NIH HHS/United States
GR  - 1RC1 AR058554/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20131006
PL  - United States
TA  - Nat Genet
JT  - Nature genetics
JID - 9216904
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Adaptive Immunity/*genetics
MH  - Genetic Association Studies
MH  - Genetic Loci/*genetics
MH  - Genetic Variation
MH  - Histocompatibility Antigens Class II/immunology
MH  - Humans
MH  - Immunity, Innate/*genetics
MH  - Sjogren's Syndrome/*genetics/*immunology
PMC - PMC3867192
MID - EMS54762
OID - NLM: EMS54762
EDAT- 2013/10/08 06:00
MHDA- 2014/01/09 06:00
PMCR- 2014/05/01
CRDT- 2013/10/08 06:00
PHST- 2013/04/27 00:00 [received]
PHST- 2013/09/11 00:00 [accepted]
PHST- 2013/10/08 06:00 [entrez]
PHST- 2013/10/08 06:00 [pubmed]
PHST- 2014/01/09 06:00 [medline]
PHST- 2014/05/01 00:00 [pmc-release]
AID - ng.2792 [pii]
AID - 10.1038/ng.2792 [doi]
PST - ppublish
SO  - Nat Genet. 2013 Nov;45(11):1284-92. doi: 10.1038/ng.2792. Epub 2013 Oct 6.