PMID- 24097110
OWN - NLM
STAT- MEDLINE
DCOM- 20131213
LR  - 20211021
IS  - 1529-2916 (Electronic)
IS  - 1529-2908 (Print)
IS  - 1529-2908 (Linking)
VI  - 14
IP  - 11
DP  - 2013 Nov
TI  - Steady-state production of IL-4 modulates immunity in mouse strains and is 
      determined by lineage diversity of iNKT cells.
PG  - 1146-54
LID - 10.1038/ni.2731 [doi]
AB  - Invariant natural killer T cells (iNKT cells) can produce copious amounts of 
      interleukin 4 (IL-4) early during infection. However, indirect evidence suggests 
      they may produce this immunomodulatory cytokine in the steady state. Through 
      intracellular staining for transcription factors, we have defined three subsets 
      of iNKT cells (NKT1, NKT2 and NKT17) that produced distinct cytokines; these 
      represented diverse lineages and not developmental stages, as previously thought. 
      These subsets exhibited substantial interstrain variation in numbers. In several 
      mouse strains, including BALB/c, NKT2 cells were abundant and were stimulated by 
      self ligands to produce IL-4. In those strains, steady-state IL-4 conditioned 
      CD8(+) T cells to become 'memory-like', increased serum concentrations of 
      immunoglobulin E (IgE) and caused dendritic cells to produce chemokines. Thus, 
      iNKT cell-derived IL-4 altered immunological properties under normal steady-state 
      conditions.
FAU - Lee, You Jeong
AU  - Lee YJ
AD  - The Department of Laboratory Medicine and Pathology, Center for Immunology, 
      University of Minnesota, Minneapolis, Minnesota, USA.
FAU - Holzapfel, Keli L
AU  - Holzapfel KL
FAU - Zhu, Jinfang
AU  - Zhu J
FAU - Jameson, Stephen C
AU  - Jameson SC
FAU - Hogquist, Kristin A
AU  - Hogquist KA
LA  - eng
GR  - T32 HD060536/HD/NICHD NIH HHS/United States
GR  - ZIA AI001169-02/Intramural NIH HHS/United States
GR  - R01 AI075168/AI/NIAID NIH HHS/United States
GR  - R37-AI39560/AI/NIAID NIH HHS/United States
GR  - R01-AI075168/AI/NIAID NIH HHS/United States
GR  - R37 AI039560/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20131006
PL  - United States
TA  - Nat Immunol
JT  - Nature immunology
JID - 100941354
RN  - 0 (Antigens, CD)
RN  - 0 (GATA3 Transcription Factor)
RN  - 0 (Gata3 protein, mouse)
RN  - 0 (Kruppel-Like Transcription Factors)
RN  - 0 (Promyelocytic Leukemia Zinc Finger Protein)
RN  - 0 (T-Box Domain Proteins)
RN  - 0 (T-box transcription factor TBX21)
RN  - 0 (Zbtb16 protein, mouse)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
EIN - Nat Immunol. 2014 Mar;15(3):305
CIN - Nat Immunol. 2013 Nov;14(11):1110-1. PMID: 24145782
MH  - Age Factors
MH  - Animals
MH  - Antigens, CD/genetics/immunology
MH  - CD8-Positive T-Lymphocytes/cytology/immunology
MH  - Cell Lineage/*immunology
MH  - Dendritic Cells/cytology/immunology
MH  - GATA3 Transcription Factor/genetics/immunology
MH  - Gene Expression Regulation
MH  - Genetic Variation/immunology
MH  - *Immunity, Innate
MH  - Immunoglobulin E/genetics/immunology
MH  - Immunologic Memory
MH  - Immunophenotyping
MH  - Interleukin-4/*biosynthesis/immunology
MH  - Kruppel-Like Transcription Factors/genetics/immunology
MH  - Mice
MH  - Natural Killer T-Cells/cytology/*immunology
MH  - Promyelocytic Leukemia Zinc Finger Protein
MH  - Species Specificity
MH  - T-Box Domain Proteins/genetics/immunology
PMC - PMC3824254
MID - NIHMS535711
COIS- Competing financial interests The authors declare no competing financial 
      interests.
EDAT- 2013/10/08 06:00
MHDA- 2013/12/18 06:00
PMCR- 2014/05/01
CRDT- 2013/10/08 06:00
PHST- 2013/07/16 00:00 [received]
PHST- 2013/09/04 00:00 [accepted]
PHST- 2013/10/08 06:00 [entrez]
PHST- 2013/10/08 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
PHST- 2014/05/01 00:00 [pmc-release]
AID - ni.2731 [pii]
AID - 10.1038/ni.2731 [doi]
PST - ppublish
SO  - Nat Immunol. 2013 Nov;14(11):1146-54. doi: 10.1038/ni.2731. Epub 2013 Oct 6.