PMID- 24099750
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20220330
IS  - 1477-0970 (Electronic)
IS  - 1352-4585 (Print)
IS  - 1352-4585 (Linking)
VI  - 20
IP  - 6
DP  - 2014 May
TI  - Oligoclonal bands and age at onset correlate with genetic risk score in multiple 
      sclerosis.
PG  - 660-8
LID - 10.1177/1352458513506503 [doi]
AB  - BACKGROUND: Many genetic risk variants are now well established in multiple 
      sclerosis (MS), but the impact on clinical phenotypes is unclear. OBJECTIVE: To 
      investigate the impact of established MS genetic risk variants on MS phenotypes, 
      in well-characterized MS cohorts. METHODS: Norwegian MS patients (n = 639) and 
      healthy controls (n = 530) were successfully genotyped for 61 established 
      MS-associated single nucleotide polymorphisms (SNPs). Data including and 
      excluding Major Histocompatibility Complex (MHC) markers were summed to a MS 
      Genetic Burden (MSGB) score. Study replication was performed in a cohort of white 
      American MS patients (n = 1997) and controls (n = 708). RESULTS: The total human 
      leukocyte antigen (HLA) and the non-HLA MSGB scores were significantly higher in 
      MS patients than in controls, in both cohorts (P << 10(-22)). MS patients, with 
      and without cerebrospinal fluid (CSF) oligoclonal bands (OCBs), had a higher MSGB 
      score than the controls; the OCB-positive patients had a slightly higher MSGB 
      than the OCB-negative patients. An early age at symptom onset (AAO) also 
      correlated with a higher MSGB score, in both cohorts. CONCLUSION: The MSGB score 
      was associated with specific clinical MS characteristics, such as OCBs and AAO. 
      This study underlines the need for well-characterized, large cohorts of MS 
      patients, and the usefulness of summarizing multiple genetic risk factors of 
      modest effect size in genotype-phenotype analyses.
FAU - Harbo, Hanne F
AU  - Harbo HF
AD  - Department of Neurology, Oslo University Hospital, Norway.
FAU - Isobe, Noriko
AU  - Isobe N
FAU - Berg-Hansen, Pal
AU  - Berg-Hansen P
FAU - Bos, Steffan D
AU  - Bos SD
FAU - Caillier, Stacy J
AU  - Caillier SJ
FAU - Gustavsen, Marte W
AU  - Gustavsen MW
FAU - Mero, Inger-Lise
AU  - Mero IL
FAU - Celius, Elisabeth Gulowsen
AU  - Celius EG
FAU - Hauser, Stephen L
AU  - Hauser SL
FAU - Oksenberg, Jorge R
AU  - Oksenberg JR
FAU - Gourraud, Pierre-Antoine
AU  - Gourraud PA
LA  - eng
GR  - R01 NS026799/NS/NINDS NIH HHS/United States
GR  - R01-NS26799/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20131007
PL  - England
TA  - Mult Scler
JT  - Multiple sclerosis (Houndmills, Basingstoke, England)
JID - 9509185
RN  - 0 (Biomarkers)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Oligoclonal Bands)
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Biomarkers/cerebrospinal fluid
MH  - Female
MH  - Genetic Testing
MH  - Genetic Variation/genetics
MH  - Genotype
MH  - Humans
MH  - Immunoglobulin G/cerebrospinal fluid
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/diagnosis/*epidemiology/*genetics
MH  - Oligoclonal Bands/*cerebrospinal fluid
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Risk Factors
PMC - PMC4066985
MID - NIHMS597972
OTO - NOTNLM
OT  - Age of onset
OT  - Multiple Sclerosis Genetic Burden
OT  - cerebrospinal fluid
OT  - genetic association
OT  - genetic risk
OT  - genotype
OT  - multiple sclerosis
OT  - oligoclonal bands
EDAT- 2013/10/09 06:00
MHDA- 2015/03/31 06:00
PMCR- 2014/06/23
CRDT- 2013/10/09 06:00
PHST- 2013/10/09 06:00 [entrez]
PHST- 2013/10/09 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
PHST- 2014/06/23 00:00 [pmc-release]
AID - 1352458513506503 [pii]
AID - 10.1177/1352458513506503 [doi]
PST - ppublish
SO  - Mult Scler. 2014 May;20(6):660-8. doi: 10.1177/1352458513506503. Epub 2013 Oct 7.