PMID- 24101259
OWN - NLM
STAT- MEDLINE
DCOM- 20140516
LR  - 20131008
IS  - 2651-5032 (Electronic)
IS  - 1019-5149 (Linking)
VI  - 23
IP  - 4
DP  - 2013
TI  - Correlation of matrix metalloproteinase-3 expression with patient age, magnetic 
      resonance imaging and histopathological grade in lumbar disc degeneration.
PG  - 427-33
LID - 10.5137/1019-5149.JTN.7459-12.0 [doi]
AB  - AIM: The purpose of the present study is to analyze the expression of matrix 
      metalloproteinase-3 (MMP-3), magnetic resonance imaging (MRI) grading and 
      histopathological alterations of the intervertebral disc (IVD) for correlations 
      with each other and with the age, gender and low back pain duration of the 
      patients who had undergone operations for lumbar disc herniation (LDH). MATERIAL 
      AND METHODS: Forty-two patients were admitted to our clinic with signs of LDH and 
      underwent surgery for LDH at 48 IVD levels. In all cases, specimens for 
      histological and immunohistochemical analyses were removed from the IVD space. 
      Lumbar IVD degeneration on MRI of the 48 IVDs from which surgical specimens had 
      been obtained was classified into five grades using the Pfirrmann classification. 
      RESULTS: In the degenerated IVD, the expression of MMP-3, MRI grading and 
      histopathological alterations of the IVD displayed significant correlation. 
      Increased age is closely related with aforementioned alterations. There was no 
      correlation between MMP-3 expression and age, gender and duration of the pain. 
      CONCLUSION: For evaluating and treating IVD degeneration, MRI is a good and 
      non-invasive diagnostic tool to determine the severity of degeneration. MMP-3 may 
      be a therapeutic target of the degenerated IVD.
FAU - Canbay, Suat
AU  - Canbay S
AD  - Oncology Training and Research Hospital, Department of Neurosurgery, Ankara, 
      Turkey.
FAU - Turhan, Nesrin
AU  - Turhan N
FAU - Bozkurt, Melih
AU  - Bozkurt M
FAU - Arda, Kemal
AU  - Arda K
FAU - Caglar, Sukru
AU  - Caglar S
LA  - eng
PT  - Journal Article
PL  - Turkey
TA  - Turk Neurosurg
JT  - Turkish neurosurgery
JID - 9423821
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aging/*metabolism
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Immunohistochemistry
MH  - Intervertebral Disc Degeneration/*enzymology/*pathology
MH  - Linear Models
MH  - Low Back Pain/etiology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Matrix Metalloproteinase 3/*biosynthesis
MH  - Middle Aged
MH  - Sex Factors
EDAT- 2013/10/09 06:00
MHDA- 2014/05/17 06:00
CRDT- 2013/10/09 06:00
PHST- 2013/10/09 06:00 [entrez]
PHST- 2013/10/09 06:00 [pubmed]
PHST- 2014/05/17 06:00 [medline]
AID - 10.5137/1019-5149.JTN.7459-12.0 [doi]
PST - ppublish
SO  - Turk Neurosurg. 2013;23(4):427-33. doi: 10.5137/1019-5149.JTN.7459-12.0.