PMID- 24103211 OWN - NLM STAT- MEDLINE DCOM- 20140826 LR - 20220330 IS - 1469-5111 (Electronic) IS - 1461-1457 (Print) IS - 1461-1457 (Linking) VI - 17 IP - 2 DP - 2014 Feb TI - Plasma brain derived neurotrophic factor (BDNF) and response to ketamine in treatment-resistant depression. PG - 331-6 LID - 10.1017/S1461145713001119 [doi] AB - Ketamine produces rapid antidepressant effects in treatment-resistant depression (TRD), but the magnitude of response varies considerably between individual patients. Brain-derived neurotrophic factor (BDNF) has been investigated as a biomarker of treatment response in depression and has been implicated in the mechanism of action of ketamine. We evaluated plasma BDNF and associations with symptoms in 22 patients with TRD enrolled in a randomized controlled trial of ketamine compared to an anaesthetic control (midazolam). Ketamine significantly increased plasma BDNF levels in responders compared to non-responders 240 min post-infusion, and Montgomery-Asberg Depression Rating Scale (MADRS) scores were negatively correlated with BDNF (r=-0.701, p = 0.008). Plasma BDNF levels at 240 min post-infusion were highly negatively associated with MADRS scores at 240 min (r = -0.897, p=.002), 24 h (r = -0.791, p = 0.038), 48 h (r = -0.944, p = 0.001) and 72 h (r = -0.977, p = 0.010). No associations with BDNF were found for patients receiving midazolam. These data support plasma BDNF as a peripheral biomarker relevant to ketamine antidepressant response. FAU - Haile, C N AU - Haile CN AD - Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA. FAU - Murrough, J W AU - Murrough JW AD - Mood and Anxiety Disorders Program, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. FAU - Iosifescu, D V AU - Iosifescu DV AD - Mood and Anxiety Disorders Program, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. FAU - Chang, L C AU - Chang LC AD - Department of Anesthesiology, Baylor College of Medicine, New York, NY, USA. FAU - Al Jurdi, R K AU - Al Jurdi RK AD - Michael E. DeBakey VA Medical Center, Houston, TX, USA. FAU - Foulkes, A AU - Foulkes A AD - Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA. FAU - Iqbal, S AU - Iqbal S AD - Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA. FAU - Mahoney, J J 3rd AU - Mahoney JJ 3rd AD - Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA. FAU - De La Garza, R 2nd AU - De La Garza R 2nd AD - Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA. FAU - Charney, D S AU - Charney DS AD - Mood and Anxiety Disorders Program, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. FAU - Newton, T F AU - Newton TF AD - Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA. FAU - Mathew, S J AU - Mathew SJ AD - Michael E. DeBakey VA Medical Center, Houston, TX, USA. LA - eng GR - K23 MH094707/MH/NIMH NIH HHS/United States GR - R01MH081870/MH/NIMH NIH HHS/United States GR - R01 MH081870/MH/NIMH NIH HHS/United States GR - 1K23MH094707-01/MH/NIMH NIH HHS/United States GR - UL1 TR000067/TR/NCATS NIH HHS/United States GR - R25 DA028976/DA/NIDA NIH HHS/United States GR - UL1TR000067/TR/NCATS NIH HHS/United States PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20131008 PL - England TA - Int J Neuropsychopharmacol JT - The international journal of neuropsychopharmacology JID - 9815893 RN - 0 (Biomarkers) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 690G0D6V8H (Ketamine) RN - 7171WSG8A2 (BDNF protein, human) RN - R60L0SM5BC (Midazolam) SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Biomarkers/blood MH - Brain-Derived Neurotrophic Factor/*blood MH - Depressive Disorder, Treatment-Resistant/*blood/diagnosis/*drug therapy MH - Double-Blind Method MH - Female MH - Humans MH - Ketamine/*therapeutic use MH - Male MH - Midazolam/therapeutic use MH - Middle Aged MH - Treatment Outcome MH - Young Adult PMC - PMC3992942 MID - NIHMS572198 EDAT- 2013/10/10 06:00 MHDA- 2014/08/27 06:00 PMCR- 2014/04/21 CRDT- 2013/10/10 06:00 PHST- 2013/10/10 06:00 [entrez] PHST- 2013/10/10 06:00 [pubmed] PHST- 2014/08/27 06:00 [medline] PHST- 2014/04/21 00:00 [pmc-release] AID - S1461145713001119 [pii] AID - 10.1017/S1461145713001119 [doi] PST - ppublish SO - Int J Neuropsychopharmacol. 2014 Feb;17(2):331-6. doi: 10.1017/S1461145713001119. Epub 2013 Oct 8.