PMID- 24103337
OWN - NLM
STAT- MEDLINE
DCOM- 20141128
LR  - 20161020
IS  - 1469-5111 (Electronic)
IS  - 1461-1457 (Linking)
VI  - 17
IP  - 1
DP  - 2014 Jan
TI  - Rapamycin prevents drug seeking via disrupting reconsolidation of reward memory 
      in rats.
PG  - 127-36
LID - 10.1017/S1461145713001156 [doi]
AB  - The maladaptive drug memory developed between the drug-rewarding effect and 
      environmental cues contributes to difficulty in preventing drug relapse. 
      Established reward memories can be disrupted by pharmacologic interventions 
      following their reactivation. Rapamycin, an inhibitor of mammalian target of 
      rapamycin (mTOR) kinase, has been proved to be involved in various memory 
      consolidation. However, it is less well characterized in drug memory 
      reconsolidation. Using a conditioned place preference (CPP) procedure, we 
      examined the effects of systemically administered rapamycin on reconsolidation of 
      drug memory in rats. We found that systemically administered rapamycin (0.1 or 
      10 mg/kg, i.p.) after re-exposure to drug-paired environment, dose dependently 
      decreased the expression of CPP 1 d later, and the effect lasted for up to 14 d 
      and could not be reversed by a priming injection of morphine. The effect of 
      rapamycin on morphine-associated memory was specific to drug-paired context, and 
      rapamycin had no effect on subsequent CPP expression when rats were exposed to 
      saline-paired context or homecage. These results indicated that systemic 
      administration of rapamycin after memory reactivation can persistently inhibit 
      the drug seeking behaviour via disruption of morphine memory reconsolidation in 
      rats. Additionally, the effect of rapamycin on memory reconsolidation was 
      reproduced in cocaine CPP and alcohol CPP. Furthermore, rapamycin did not induce 
      conditioned place aversion and had no effect on locomotor activity and anxiety 
      behaviour. These findings suggest that rapamycin could erase the acquired drug 
      CPP in rats, and that mTOR activity plays an important role in drug 
      reconsolidation and is required for drug relapse.
FAU - Lin, Jue
AU  - Lin J
AD  - Key Laboratory of Combinatorial Biosynthesis and Drug Discovery Wuhan University, 
      Ministry of Education, and Wuhan University School of Pharmaceutical Sciences, 
      Wuhan, Hubei 430071, China.
FAU - Liu, Lingqi
AU  - Liu L
FAU - Wen, Quan
AU  - Wen Q
FAU - Zheng, Chunming
AU  - Zheng C
FAU - Gao, Yang
AU  - Gao Y
FAU - Peng, Shuxian
AU  - Peng S
FAU - Tan, Yalun
AU  - Tan Y
FAU - Li, Yanqin
AU  - Li Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131008
PL  - England
TA  - Int J Neuropsychopharmacol
JT  - The international journal of neuropsychopharmacology
JID - 9815893
RN  - 0 (Protein Kinase Inhibitors)
RN  - 3K9958V90M (Ethanol)
RN  - 76I7G6D29C (Morphine)
RN  - I5Y540LHVR (Cocaine)
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
MH  - Animals
MH  - Cocaine/antagonists & inhibitors/pharmacology
MH  - Conditioning, Classical/drug effects
MH  - Cues
MH  - Drug-Seeking Behavior/*drug effects
MH  - Ethanol/antagonists & inhibitors/pharmacology
MH  - Male
MH  - Maze Learning/drug effects
MH  - Memory/*drug effects
MH  - Morphine/antagonists & inhibitors/pharmacology
MH  - Motor Activity/drug effects
MH  - Protein Kinase Inhibitors/*pharmacology
MH  - Rats
MH  - *Reward
MH  - Sirolimus/*pharmacology
EDAT- 2013/10/10 06:00
MHDA- 2014/12/15 06:00
CRDT- 2013/10/10 06:00
PHST- 2013/10/10 06:00 [entrez]
PHST- 2013/10/10 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - S1461145713001156 [pii]
AID - 10.1017/S1461145713001156 [doi]
PST - ppublish
SO  - Int J Neuropsychopharmacol. 2014 Jan;17(1):127-36. doi: 
      10.1017/S1461145713001156. Epub 2013 Oct 8.