PMID- 24104932
OWN - NLM
STAT- MEDLINE
DCOM- 20140326
LR  - 20131009
IS  - 1536-4798 (Electronic)
IS  - 0277-3740 (Linking)
VI  - 32 Suppl 1
DP  - 2013 Nov
TI  - Multidrug-resistant bacteria induce recurrent keratoconjunctivitis in a patient 
      with common variable immunodeficiency: case report and literature review.
PG  - S39-42
LID - 10.1097/ICO.0b013e3182a2c7e6 [doi]
AB  - PURPOSE: We present a case study regarding a patient with recurrent 
      keratoconjunctivitis that presented as an initial manifestation of common 
      variable immunodeficiency (CVID). METHODS: We describe a case and review the 
      recent relevant medical literature. RESULTS: A 33-year-old male had recurrent 
      keratoconjunctivitis induced by multidrug-resistant bacteria. Topical vancomycin 
      treatment was effective, but infection recurred when the vancomycin treatment was 
      stopped. The patient was transferred to the Department of Medicine to rule out 
      potential systemic immune diseases and was finally diagnosed with CVID. 
      Intravenous immunoglobulin (IVIG) was administered, and the patient was followed 
      up monthly without any recurrence of infection to date. IVIG will be administered 
      monthly for the patient's lifetime. CONCLUSIONS: Keratoconjunctivitis is a 
      CVID-associated manifestation, sometimes appearing as the first presentation. 
      CVID should be considered when unexplained recurrent conjunctival and/or corneal 
      bacterial infections are observed. Topical therapy is not sufficient to treat 
      this infection and IVIG is necessary.
FAU - Chao, Jiang
AU  - Chao J
AD  - Beijing Ophthalmology & Visual Sciences Key Lab, Beijing Tongren Eye Center, 
      Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University 
      of Medical Science, Beijing, China.
FAU - Yumei, Zhou
AU  - Yumei Z
FAU - Zhiqun, Wang
AU  - Zhiqun W
FAU - Yang, Zhang
AU  - Yang Z
FAU - Xuguang, Sun
AU  - Xuguang S
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Cornea
JT  - Cornea
JID - 8216186
SB  - IM
MH  - Adult
MH  - Bacterial Infections/*etiology
MH  - Common Variable Immunodeficiency/*complications
MH  - *Drug Resistance, Multiple, Bacterial
MH  - Humans
MH  - Keratoconjunctivitis/*microbiology
MH  - Male
MH  - Recurrence
MH  - Streptococcus/isolation & purification
EDAT- 2013/10/23 06:00
MHDA- 2014/03/29 06:00
CRDT- 2013/10/10 06:00
PHST- 2013/10/10 06:00 [entrez]
PHST- 2013/10/23 06:00 [pubmed]
PHST- 2014/03/29 06:00 [medline]
AID - 00003226-201311001-00007 [pii]
AID - 10.1097/ICO.0b013e3182a2c7e6 [doi]
PST - ppublish
SO  - Cornea. 2013 Nov;32 Suppl 1:S39-42. doi: 10.1097/ICO.0b013e3182a2c7e6.