PMID- 24105077
OWN - NLM
STAT- MEDLINE
DCOM- 20141224
LR  - 20220321
IS  - 1438-2199 (Electronic)
IS  - 0939-4451 (Linking)
VI  - 45
IP  - 6
DP  - 2013 Dec
TI  - Indoleamine 2,3-dioxygenase 2 (IDO2) and the kynurenine pathway: characteristics 
      and potential roles in health and disease.
PG  - 1319-29
LID - 10.1007/s00726-013-1602-1 [doi]
AB  - The kynurenine pathway is the major route for the oxidative degradation of the 
      amino acid tryptophan. Activity of the pathway is involved in several disease 
      conditions, both in the periphery and the central nervous system, including 
      cancer, inflammatory disorders, neurological conditions, psychiatric disorders 
      and neurodegenerative diseases. Three enzymes are now known to catalyze the first 
      and rate-limiting step in the catabolism of tryptophan along this pathway: 
      tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO, 
      subsequently named IDO1), both of which have been extensively studied, and a 
      third enzyme, indoleamine 2,3-dioxygenase 2 (IDO2), a relative newcomer to the 
      kynurenine pathway field. The adjuvant chemotherapeutic agent, 
      1-methyl-D-tryptophan, was intially suggested to target IDO2, implying 
      involvement of IDO2 in tumorigenesis. Subsequently this compound has been 
      suggested to have alternative actions and the physiological and 
      pathophysiological roles of IDO2 are unclear. Targeted genetic interventions and 
      selective inhibitors provide approaches for investigating the biology of IDO2. 
      This review focuses on the current knowledge of IDO2 biology and discusses tools 
      that will assist in further characterizing the enzymes of the kynurenine pathway.
FAU - Fatokun, Amos A
AU  - Fatokun AA
AD  - School of Biomedical Sciences, Institute of Cell Signalling, The University of 
      Nottingham, Nottingham, NG7 2UH, UK.
FAU - Hunt, Nicholas H
AU  - Hunt NH
FAU - Ball, Helen J
AU  - Ball HJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20131009
PL  - Austria
TA  - Amino Acids
JT  - Amino acids
JID - 9200312
RN  - 0 (IDO2 protein, human)
RN  - 0 (IDO2 protein, mouse)
RN  - 0 (Indoleamine-Pyrrole 2,3,-Dioxygenase)
RN  - 343-65-7 (Kynurenine)
SB  - IM
MH  - Animals
MH  - Disease
MH  - Health
MH  - Humans
MH  - Indoleamine-Pyrrole 2,3,-Dioxygenase/*metabolism
MH  - Kynurenine/*metabolism
EDAT- 2013/10/10 06:00
MHDA- 2014/12/30 06:00
CRDT- 2013/10/10 06:00
PHST- 2013/05/22 00:00 [received]
PHST- 2013/09/25 00:00 [accepted]
PHST- 2013/10/10 06:00 [entrez]
PHST- 2013/10/10 06:00 [pubmed]
PHST- 2014/12/30 06:00 [medline]
AID - 10.1007/s00726-013-1602-1 [doi]
PST - ppublish
SO  - Amino Acids. 2013 Dec;45(6):1319-29. doi: 10.1007/s00726-013-1602-1. Epub 2013 
      Oct 9.