PMID- 24105390
OWN - NLM
STAT- MEDLINE
DCOM- 20140619
LR  - 20180913
IS  - 1536-4844 (Electronic)
IS  - 1078-0998 (Linking)
VI  - 19
IP  - 12
DP  - 2013 Nov
TI  - Reduced fat oxidation rates during submaximal exercise in adolescents with 
      Crohn's disease.
PG  - 2659-65
LID - 10.1097/01.MIB.0000436958.54663.4f [doi]
AB  - BACKGROUND: Children with Crohn's disease (CD) suffer from malnutrition. 
      Understanding substrate utilization during exercise may help patients with CD 
      sustain a healthy active lifestyle without compromising nutrition. The aim of 
      this study was to determine whether substrate utilization and bioavailability 
      during exercise are altered in children with CD compared with controls. METHODS: 
      Seven children with CD (mean age +/- SD: 15.2 +/- 2.3 yr) and 7 controls (14.4 +/- 2.3 
      yr) were matched by sex and biological age. Participants completed 60 minutes of 
      cycling at an intensity equivalent to 50% of their peak mechanical power. Rates 
      of total fat and carbohydrate (CHO) oxidation, the amount of fat and CHO 
      oxidized, and the contribution of fat and CHO to total energy expenditure were 
      calculated from expired gases collected during exercise. Blood was collected 
      before, during, and at the end of exercise and analyzed for insulin, free fatty 
      acids, and glucose. RESULTS: Whole-body fat oxidation rate (expressed in mg . 
      kg(-1) of body weight per min) during exercise was lower in children with CD (5.8 
      +/- 1.0) compared with controls (8.0 +/- 2.2, P < 0.05). Children with CD relied 
      significantly more on CHO, with approximately 10% greater contribution toward 
      total energy expenditure (P < 0.05) than controls. There were no differences in 
      plasma insulin, free fatty acids, or glucose between the groups. CONCLUSIONS: Fat 
      metabolism during exercise seems to be impaired in children with CD. A greater 
      reliance on CHO is required to meet the energy demands of submaximal exercise.
FAU - Nguyen, Thanh
AU  - Nguyen T
AD  - *Child Health & Exercise Medicine Program, McMaster University, Hamilton, 
      Ontario, Canada; daggerDepartment of Rehabilitation, Academic Medical Center, 
      University of Amsterdam, Amsterdam, the Netherlands; double daggerMcMaster Children's 
      Hospital, Hamilton, Ontario, Canada;  section signExercise Metabolism Research Group, 
      Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada; and 
       ||University Medical Center Utrecht, Utrecht, The Netherlands.
FAU - Ploeger, Hilde E
AU  - Ploeger HE
FAU - Obeid, Joyce
AU  - Obeid J
FAU - Issenman, Robert M
AU  - Issenman RM
FAU - Baker, Jeff M
AU  - Baker JM
FAU - Takken, Tim
AU  - Takken T
FAU - Parise, Gianni
AU  - Parise G
FAU - Timmons, Brian W
AU  - Timmons BW
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Inflamm Bowel Dis
JT  - Inflammatory bowel diseases
JID - 9508162
RN  - 0 (Blood Glucose)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Insulin)
SB  - IM
MH  - Adipose Tissue/*chemistry
MH  - Adolescent
MH  - Blood Glucose/metabolism
MH  - Carbohydrate Metabolism
MH  - Case-Control Studies
MH  - Crohn Disease/*metabolism/*pathology
MH  - Exercise/*physiology
MH  - Fatty Acids, Nonesterified/metabolism
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Insulin/metabolism
MH  - *Lipid Metabolism
MH  - Male
MH  - Oxidation-Reduction
MH  - Prognosis
EDAT- 2013/10/10 06:00
MHDA- 2014/06/20 06:00
CRDT- 2013/10/10 06:00
PHST- 2013/10/10 06:00 [entrez]
PHST- 2013/10/10 06:00 [pubmed]
PHST- 2014/06/20 06:00 [medline]
AID - 10.1097/01.MIB.0000436958.54663.4f [doi]
PST - ppublish
SO  - Inflamm Bowel Dis. 2013 Nov;19(12):2659-65. doi: 
      10.1097/01.MIB.0000436958.54663.4f.