PMID- 24105754
OWN - NLM
STAT- MEDLINE
DCOM- 20141114
LR  - 20220321
IS  - 1532-2149 (Electronic)
IS  - 1090-3801 (Linking)
VI  - 18
IP  - 4
DP  - 2014 Apr
TI  - Characterization of a porcine model of post-operative pain.
PG  - 496-505
LID - 10.1002/j.1532-2149.2013.00399.x [doi]
AB  - BACKGROUND: Management of acute pain related to surgical intervention, termed 
      post-operative pain or POP, continues to be a major healthcare challenge. While 
      the rat plantar incision model provides valuable data to researchers about the 
      mechanisms mediating POP, the development of topical and localized treatments in 
      small animal models is limited. To help address these issues, we describe here 
      the characterization of a large animal model of incisional pain. METHODS: Pigs 
      underwent full-skin incision or full-skin and muscle incision and retraction 
      (SMIR). Withdrawal thresholds were determined using the Von Frey test at 
      baseline, 0.5-12 h post-surgery and on days 1, 2, 3, 5 and 7 post-surgery. The 
      analgesic effects of systemic morphine [0.1 or 1.0 mg/kg intramuscular (i.m.) 
      dose] and local anaesthetic ropivacaine were studied. Spontaneous pain-like 
      behaviours were scored and analysed. The effects on wound healing were evaluated 
      by gross observation and by histopathological examination. RESULTS: Pigs 
      incurring SMIR demonstrated significantly increased mechanical hypersensitivity 
      compared with pigs that underwent full-skin incision only (p < 0.05). Maximal 
      analgesia was achieved with morphine (1 mg/kg i.m. dose) at 0.5 h post-treatment. 
      Local treatment with ropivacaine was effective at increasing the withdrawal 
      threshold to Von Frey filaments compared with saline control (p < 0.05) for a 
      period of at least 6 h. Wounds healed normally with no signs of infection, 
      redness or swelling. CONCLUSIONS: We propose that the pig model of incisional 
      pain can provide an appropriate translational model for validating new topical 
      and localized treatments for POP in humans.
CI  - (c) 2013 European Pain Federation - EFIC(R)
FAU - Castel, D
AU  - Castel D
AD  - The Neufeld Cardiac Research Institute and Department of Physiology and 
      Pharmacology, Sackler School of Medicine, Tel-Aviv University, Israel.
FAU - Willentz, E
AU  - Willentz E
FAU - Doron, O
AU  - Doron O
FAU - Brenner, O
AU  - Brenner O
FAU - Meilin, S
AU  - Meilin S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130916
PL  - England
TA  - Eur J Pain
JT  - European journal of pain (London, England)
JID - 9801774
RN  - 0 (Analgesics, Opioid)
RN  - 76I7G6D29C (Morphine)
SB  - IM
MH  - Analgesics, Opioid/*therapeutic use
MH  - Animals
MH  - Dermatologic Surgical Procedures/methods
MH  - Disease Models, Animal
MH  - Morphine/*therapeutic use
MH  - Pain Measurement
MH  - Pain Threshold/physiology
MH  - Pain, Postoperative/*drug therapy
MH  - Skin/physiopathology
MH  - Swine
EDAT- 2013/10/10 06:00
MHDA- 2014/11/15 06:00
CRDT- 2013/10/10 06:00
PHST- 2013/08/10 00:00 [accepted]
PHST- 2013/10/10 06:00 [entrez]
PHST- 2013/10/10 06:00 [pubmed]
PHST- 2014/11/15 06:00 [medline]
AID - 10.1002/j.1532-2149.2013.00399.x [doi]
PST - ppublish
SO  - Eur J Pain. 2014 Apr;18(4):496-505. doi: 10.1002/j.1532-2149.2013.00399.x. Epub 
      2013 Sep 16.