PMID- 24105840
OWN - NLM
STAT- MEDLINE
DCOM- 20140217
LR  - 20200304
IS  - 1473-5644 (Electronic)
IS  - 0022-2615 (Linking)
VI  - 63
IP  - Pt 1
DP  - 2014 Jan
TI  - Klebsiella pneumoniae meningitis induces memory impairment and increases 
      pro-inflammatory host response in the central nervous system of Wistar rats.
PG  - 111-117
LID - 10.1099/jmm.0.063289-0 [doi]
AB  - Klebsiella pneumoniae meningitis has recently become an increasingly common cause 
      of central nervous system infection. The invasion of bacteria within the 
      subarachnoid space stimulates the release of pro-inflammatory cytokines and 
      chemokines, triggering a host immune response. The aim of the present study was 
      to evaluate memory and pro-inflammatory mediators at different times in the 
      brains of adult Wistar rats with K. pneumoniae meningitis. The animals were 
      sacrificed at 6, 12, 24, 48 and 96 h after meningitis induction. The hippocampus, 
      frontal cortex and cerebrospinal fluid were isolated to determine the cytokine, 
      chemokine and brain-derived neurotrophic factor (BDNF) levels. In the first 6 and 
      24 h following meningitis induction, there was a significant increase of the 
      TNF-alpha, IL-1beta, IL-6, cytokine-induced neutrophil chemoattractant-1 and BDNF levels 
      in the central nervous system. Ten days after meningitis induction, cognitive 
      memory was evaluated using an open-field task and step-down inhibitory avoidance 
      task. In the control group, significant differences in behaviour were observed 
      between the training and testing sessions for both tasks, demonstrating 
      habituation and aversive memory. However, the meningitis group did not exhibit 
      any difference between the training and testing sessions in either task, 
      demonstrating memory impairment. As a result of these observations, we believe 
      that the meningitis model may be a good research tool to study the biological 
      mechanisms involved in the pathophysiology of this illness, while recognizing 
      that animal models should be interpreted with caution before extrapolation to the 
      clinic.
FAU - Barichello, Tatiana
AU  - Barichello T
AD  - Laboratorio de Microbiologia Experimental, Programa de Pos-Graduacao em Ciencias 
      da Saude, Unidade Academica de Ciencias da Saude, Universidade do Extremo Sul 
      Catarinense, Criciuma, SC, Brazil.
FAU - Simoes, Lutiana R
AU  - Simoes LR
AD  - Laboratorio de Microbiologia Experimental, Programa de Pos-Graduacao em Ciencias 
      da Saude, Unidade Academica de Ciencias da Saude, Universidade do Extremo Sul 
      Catarinense, Criciuma, SC, Brazil.
FAU - Valvassori, Samira S
AU  - Valvassori SS
AD  - Laboratorio de Neurociencias, Programa de Pos-Graduacao em Ciencias da Saude, 
      Unidade Academica de Ciencias da Saude, Universidade do Extremo Sul Catarinense, 
      Criciuma, SC, Brazil.
FAU - Generoso, Jaqueline S
AU  - Generoso JS
AD  - Laboratorio de Microbiologia Experimental, Programa de Pos-Graduacao em Ciencias 
      da Saude, Unidade Academica de Ciencias da Saude, Universidade do Extremo Sul 
      Catarinense, Criciuma, SC, Brazil.
FAU - Aveline, Paulo Eduardo D V
AU  - Aveline PEDV
AD  - Laboratorio de Microbiologia Experimental, Programa de Pos-Graduacao em Ciencias 
      da Saude, Unidade Academica de Ciencias da Saude, Universidade do Extremo Sul 
      Catarinense, Criciuma, SC, Brazil.
FAU - Dominguini, Diogo
AU  - Dominguini D
AD  - Laboratorio de Neurociencias, Programa de Pos-Graduacao em Ciencias da Saude, 
      Unidade Academica de Ciencias da Saude, Universidade do Extremo Sul Catarinense, 
      Criciuma, SC, Brazil.
FAU - Elias, Samuel G
AU  - Elias SG
AD  - Laboratorio de Microbiologia Experimental, Programa de Pos-Graduacao em Ciencias 
      da Saude, Unidade Academica de Ciencias da Saude, Universidade do Extremo Sul 
      Catarinense, Criciuma, SC, Brazil.
FAU - Vilela, Marcia C
AU  - Vilela MC
AD  - Laboratorio de Imunofarmacologia, Departamento de Bioquimica e Imunologia, 
      Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo 
      Horizonte, MG, Brazil.
FAU - Quevedo, Joao
AU  - Quevedo J
AD  - Laboratorio de Neurociencias, Programa de Pos-Graduacao em Ciencias da Saude, 
      Unidade Academica de Ciencias da Saude, Universidade do Extremo Sul Catarinense, 
      Criciuma, SC, Brazil.
FAU - Teixeira, Antonio Lucio
AU  - Teixeira AL
AD  - Laboratorio de Imunofarmacologia, Departamento de Bioquimica e Imunologia, 
      Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo 
      Horizonte, MG, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131008
PL  - England
TA  - J Med Microbiol
JT  - Journal of medical microbiology
JID - 0224131
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/analysis
MH  - Central Nervous System/immunology/*pathology
MH  - Cerebral Cortex/chemistry/pathology
MH  - Cerebrospinal Fluid/chemistry
MH  - Cytokines/*analysis
MH  - Disease Models, Animal
MH  - Hippocampus/chemistry/pathology
MH  - Klebsiella Infections/*complications/*pathology
MH  - Klebsiella pneumoniae/growth & development
MH  - Male
MH  - Memory Disorders/*etiology
MH  - Meningitis, Bacterial/*complications/*pathology
MH  - Rats
MH  - Rats, Wistar
MH  - Time Factors
EDAT- 2013/10/10 06:00
MHDA- 2014/02/18 06:00
CRDT- 2013/10/10 06:00
PHST- 2013/10/10 06:00 [entrez]
PHST- 2013/10/10 06:00 [pubmed]
PHST- 2014/02/18 06:00 [medline]
AID - 10.1099/jmm.0.063289-0 [doi]
PST - ppublish
SO  - J Med Microbiol. 2014 Jan;63(Pt 1):111-117. doi: 10.1099/jmm.0.063289-0. Epub 
      2013 Oct 8.