PMID- 24105909
OWN - NLM
STAT- MEDLINE
DCOM- 20141110
LR  - 20220317
IS  - 1932-8737 (Electronic)
IS  - 0160-9289 (Print)
IS  - 0160-9289 (Linking)
VI  - 36
IP  - 11
DP  - 2013 Nov
TI  - Gender-related safety and efficacy of cardiac resynchronization therapy.
PG  - 683-90
LID - 10.1002/clc.22203 [doi]
AB  - BACKGROUND: Cardiac resynchronization therapy (CRT) is an established therapy for 
      patients with chronic heart failure (CHF) and a broad QRS complex. Gender-related 
      safety and efficacy data are necessary for informed patient decision-making for 
      female patients with CHF. The aim of the study was to assess the effects of 
      gender on the outcome of CRT in highly symptomatic heart failure patients. 
      HYPOTHESIS: Gender may have an effect on the outcome of heart failure patients 
      undergoing cardiac resynchronisation therapy. METHODS: The study analyzed the 
      2-year follow-up of 393 New York Heart Association (NYHA) class III/IV patients 
      with a class I CRT indication enrolled in the Management of Atrial Fibrillation 
      Suppression in AF-HF Comorbidity Therapy (MASCOT) study. RESULTS: In female 
      patients (n = 82), compared with male patients (n = 311), CHF was more often due 
      to dilated cardiomyopathy (74% vs 44%, respectively; P < 0.0001). Females also 
      had a more impaired quality-of-life score and a smaller left ventricular 
      end-diastolic diameter (LVEDD). Women were less likely than men to have received 
      a CRT defibrillator (35% vs 61%, respectively; P < 0.0001). After 2 years, the 
      devices had delivered more biventricular pacing in women than in men (96% +/- 13% 
      vs 94% +/- 13%, respectively; P < 0.0004). Women had a greater reduction in LVEDD 
      than did men (-8.2 mm +/- 11.1 mm vs -1.1 mm +/- 22.1 mm, respectively; P < 0.02). 
      Both genders improved similarly in NYHA functional class. Women reported greater 
      improvement than men in quality-of-life score (-21.1 +/- 26.5 vs -16.2 +/- 22.1, 
      respectively; P < 0.0001). After adjustment for cardiovascular history, women had 
      lower all-cause mortality (P = 0.0007), less cardiac death (P = 0.04), and fewer 
      hospitalizations for worsening heart failure (P = 0.01). CONCLUSIONS: Females 
      exhibited a better response to CRT than did males. Because females have such 
      impressive benefits from CRT, improved screening and advocacy for CRT 
      implantation in women should be considered.
CI  - (c) 2013 Wiley Periodicals, Inc.
FAU - Schuchert, Andreas
AU  - Schuchert A
AD  - Medical Clinic, Friedrich-Ebert Hospital, Neumunster, Germany.
FAU - Muto, Carmine
AU  - Muto C
FAU - Maounis, Themistoklis
AU  - Maounis T
FAU - Frank, Robert
AU  - Frank R
FAU - Ella, Rita Omega
AU  - Ella RO
FAU - Polauck, Alexander
AU  - Polauck A
FAU - Padeletti, Luigi
AU  - Padeletti L
CN  - MASCOT Study Group
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20130917
PL  - United States
TA  - Clin Cardiol
JT  - Clinical cardiology
JID - 7903272
SB  - IM
MH  - Aged
MH  - *Cardiac Resynchronization Therapy/adverse effects/mortality
MH  - Chronic Disease
MH  - Europe
MH  - Female
MH  - Health Status Disparities
MH  - Healthcare Disparities
MH  - Heart Failure/diagnosis/mortality/physiopathology/*therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Quality of Life
MH  - Recovery of Function
MH  - Risk Assessment
MH  - Risk Factors
MH  - Sex Factors
MH  - Single-Blind Method
MH  - Stroke Volume
MH  - Time Factors
MH  - Treatment Outcome
MH  - Ventricular Function, Left
PMC - PMC6649589
FIR - Acquati, Fiorenzo
IR  - Acquati F
FIR - Alessandrini, Francesco
IR  - Alessandrini F
FIR - Bongiorni, Maria-Grazia
IR  - Bongiorni MG
FIR - Brachmann, Johannes
IR  - Brachmann J
FIR - Calvi, Valeria
IR  - Calvi V
FIR - Chan, Ngai-yin
IR  - Chan NY
FIR - Christensen, Per Dahl
IR  - Christensen PD
FIR - Fiorello, Pierre
IR  - Fiorello P
FIR - Flammang, Daniel
IR  - Flammang D
FIR - Foti, Francesco
IR  - Foti F
FIR - Frank, Robert
IR  - Frank R
FIR - Fusco, Antonio
IR  - Fusco A
FIR - Goode, Grahame
IR  - Goode G
FIR - Gras, Daniel
IR  - Gras D
FIR - Gruska, Michael
IR  - Gruska M
FIR - Jauvert, Gael
IR  - Jauvert G
FIR - Kachboura, Salem
IR  - Kachboura S
FIR - Kaltofen, Gert
IR  - Kaltofen G
FIR - Kiowski, Wolfgang
IR  - Kiowski W
FIR - Lisi, Francesco
IR  - Lisi F
FIR - Maounis, Themistoklis
IR  - Maounis T
FIR - Occhetta, Eraldo
IR  - Occhetta E
FIR - Padeletti, Luigi
IR  - Padeletti L
FIR - Piot, Olivier
IR  - Piot O
FIR - Poulard, Jean-Ernst
IR  - Poulard JE
FIR - Rey, Jean-Luc
IR  - Rey JL
FIR - Saoudi, Nadir
IR  - Saoudi N
FIR - Schuchert, Andreas
IR  - Schuchert A
FIR - Thomas, Olivier
IR  - Thomas O
FIR - Tuccillo, Bernardo
IR  - Tuccillo B
FIR - Vesterlund, Thomas
IR  - Vesterlund T
FIR - Vock, Paul
IR  - Vock P
FIR - Weide, Arnd
IR  - Weide A
FIR - Zecchi, Paolo
IR  - Zecchi P
EDAT- 2013/10/10 06:00
MHDA- 2014/11/11 06:00
PMCR- 2013/09/17
CRDT- 2013/10/10 06:00
PHST- 2013/06/21 00:00 [received]
PHST- 2013/08/01 00:00 [revised]
PHST- 2013/10/10 06:00 [entrez]
PHST- 2013/10/10 06:00 [pubmed]
PHST- 2014/11/11 06:00 [medline]
PHST- 2013/09/17 00:00 [pmc-release]
AID - CLC22203 [pii]
AID - 10.1002/clc.22203 [doi]
PST - ppublish
SO  - Clin Cardiol. 2013 Nov;36(11):683-90. doi: 10.1002/clc.22203. Epub 2013 Sep 17.