PMID- 24106238
OWN - NLM
STAT- MEDLINE
DCOM- 20141020
LR  - 20160511
IS  - 2042-6984 (Electronic)
IS  - 2042-6976 (Linking)
VI  - 4
IP  - 1
DP  - 2014 Jan
TI  - Specific inhalation challenge with flour induced release of brain-derived 
      neurotrophic factor in nasal fluid.
PG  - 49-55
LID - 10.1002/alr.21223 [doi]
AB  - BACKGROUND: Neurotrophins may play a role in the pathophysiology of allergic 
      occupational rhinitis (OR). We sought to investigate whether an immediate 
      allergic reaction that induces nasal inflammation is also able to induce changes 
      in levels of brain-derived neurotrophic factor (BDNF) in nasal lavage (NAL) fluid 
      from patients with allergic OR. METHODS: Ten patients sensitized to flour 
      underwent control and active specific inhalation challenge (SIC) on consecutive 
      days. Nasal response to SIC was monitored with acoustic rhinometry and symptoms 
      recording. NAL was performed before and 30 minutes, 6 hours, and 24 hours after 
      control and active challenge for the assessment of levels of BDNF and 
      inflammatory cells in NAL fluid. RESULTS: In contrast to control day, flour 
      challenge induced immediate clinical reactions in all subjects. After flour 
      challenge, a significant increase in levels of BDNF in NAL fluid was observed at 
      6 hours after challenge (p < 0.05). Also, a significant increase in the number of 
      eosinophils in NAL fluid at 30 minutes (p < 0.01), 6 hours (p < 0.01), and 24 
      hours (p = 0.05) postchallenge was observed. Also, levels of BDNF in NAL fluid 
      were significantly higher at 30 minutes after flour challenge (p = 0.02) in 
      comparison to levels on the control day at the same postchallenge time. A 
      marginally significant positive correlation between BDNF levels and eosinophil 
      counts at 30 minutes (r = 0.60, p = 0.06) and at 6 hours (r = 0.50, p = 0.08) 
      after flour challenge was noted. CONCLUSION: We showed that BDNF is released in 
      nasal fluid after SIC with flour. Results support the suggestion that 
      neurotrophins may play a role in the pathogenesis of allergic OR.
CI  - (c) 2013 ARS-AAOA, LLC.
FAU - Castano, Roberto
AU  - Castano R
AD  - Division of Otolaryngology-Head and Neck Surgery, University of Montreal, 
      Montreal, Canada; Chronic Disease Research Division, Hopital du Sacre-Coeur de 
      Montreal, Montreal, Canada.
FAU - Welman, Melanie
AU  - Welman M
FAU - Trudeau, Carole
AU  - Trudeau C
FAU - Castellanos, Lucero
AU  - Castellanos L
FAU - Maghni, Karim
AU  - Maghni K
FAU - Malo, Jean-Luc
AU  - Malo JL
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130917
PL  - United States
TA  - Int Forum Allergy Rhinol
JT  - International forum of allergy & rhinology
JID - 101550261
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Eosinophils/*metabolism
MH  - Female
MH  - Flour/*adverse effects
MH  - Humans
MH  - Hypersensitivity/immunology/metabolism
MH  - Male
MH  - Middle Aged
MH  - Nasal Lavage Fluid/*chemistry
MH  - Occupational Diseases/*immunology/metabolism
MH  - Rhinitis, Allergic, Perennial/*immunology/metabolism
MH  - Rhinometry, Acoustic
MH  - Time Factors
OTO - NOTNLM
OT  - brain-derived neurotrophic factor
OT  - nasal challenge
OT  - nasal lavage
OT  - neurotrophins
OT  - occupational rhinitis
OT  - rhinitis
EDAT- 2013/10/10 06:00
MHDA- 2014/10/21 06:00
CRDT- 2013/10/10 06:00
PHST- 2013/01/14 00:00 [received]
PHST- 2013/06/19 00:00 [revised]
PHST- 2013/07/26 00:00 [accepted]
PHST- 2013/10/10 06:00 [entrez]
PHST- 2013/10/10 06:00 [pubmed]
PHST- 2014/10/21 06:00 [medline]
AID - 10.1002/alr.21223 [doi]
PST - ppublish
SO  - Int Forum Allergy Rhinol. 2014 Jan;4(1):49-55. doi: 10.1002/alr.21223. Epub 2013 
      Sep 17.