PMID- 24106582
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131009
LR  - 20211021
IS  - 2005-6443 (Print)
IS  - 2092-6715 (Electronic)
IS  - 2005-6443 (Linking)
VI  - 34
IP  - 5
DP  - 2013 Sep
TI  - Postmarketing surveillance study of the efficacy and safety of phentermine in 
      patients with obesity.
PG  - 298-306
LID - 10.4082/kjfm.2013.34.5.298 [doi]
AB  - BACKGROUND: Obesity is a complex problem that is now considered a chronic 
      metabolic disease. In Korea, phentermine has been widely used for the treatment 
      of obesity in the primary care setting since 2004. However, there have been very 
      few studies on the safety and efficacy of phentermine. To investigate the safety 
      and efficacy of this drug, a postmarketing surveillance study was performed. 
      METHODS: A total of 795 patients with obesity (body mass index >/= 25 kg/m(2)) were 
      enrolled from 30 primary care centers in Korea from September 2006 to November 
      2007. Patients were examined to ascertain safety and efficacy at 4-, 8-, and 
      12-week intervals. The criterion for efficacy was defined as a weight loss >/= 5% 
      of body weight. RESULTS: Of the 795 enrolled patients, 735 (92.5%) were evaluated 
      in safety assessments and 711 (89.4%) was included in efficacy assessments. A 
      total of 266 adverse events (AEs) were reported by 218 patients (30.6%), and no 
      serious AEs were reported. Among 711 patients, 324 patients (45.6%) lost >/= 5% of 
      their body weight. The mean weight loss was 3.8 +/- 4.0 kg. CONCLUSION: AEs are 
      commonly associated with phentermine, even though phentermine is effective for 
      weight loss and relatively well-tolerated.
FAU - Kim, Hyun Ok
AU  - Kim HO
AD  - Department of Family Medicine, Asan Medical Center, University of Ulsan College 
      of Medicine, Seoul, Korea.
FAU - Lee, Jung Ah
AU  - Lee JA
FAU - Suh, Hee Won
AU  - Suh HW
FAU - Kim, Young Sik
AU  - Kim YS
FAU - Kim, Bum Soo
AU  - Kim BS
FAU - Ahn, Eun Sook
AU  - Ahn ES
FAU - Roh, Young Jun
AU  - Roh YJ
FAU - Jung, Seong Gil
AU  - Jung SG
FAU - Kim, Jin Mok
AU  - Kim JM
FAU - Kang, Moon Kuk
AU  - Kang MK
FAU - Ahn, In Soon
AU  - Ahn IS
FAU - Park, Young Gyu
AU  - Park YG
LA  - eng
PT  - Journal Article
DEP - 20130926
PL  - Korea (South)
TA  - Korean J Fam Med
JT  - Korean journal of family medicine
JID - 101502902
PMC - PMC3791337
OTO - NOTNLM
OT  - Efficacy
OT  - Obesity
OT  - Phentermine
OT  - Safety
COIS- No potential conflict of interest relevant to this article was reported.
EDAT- 2013/10/10 06:00
MHDA- 2013/10/10 06:01
PMCR- 2013/09/01
CRDT- 2013/10/10 06:00
PHST- 2011/08/31 00:00 [received]
PHST- 2013/08/22 00:00 [accepted]
PHST- 2013/10/10 06:00 [entrez]
PHST- 2013/10/10 06:00 [pubmed]
PHST- 2013/10/10 06:01 [medline]
PHST- 2013/09/01 00:00 [pmc-release]
AID - 10.4082/kjfm.2013.34.5.298 [doi]
PST - ppublish
SO  - Korean J Fam Med. 2013 Sep;34(5):298-306. doi: 10.4082/kjfm.2013.34.5.298. Epub 
      2013 Sep 26.