PMID- 24106597
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131009
LR  - 20211021
IS  - 2008-3866 (Print)
IS  - 2008-3874 (Electronic)
IS  - 2008-3866 (Linking)
VI  - 16
IP  - 8
DP  - 2013 Aug
TI  - Pentoxifylline Protects the Rat Liver Against Fibrosis and Apoptosis Induced by 
      Acute Administration of 3,4-Methylenedioxymethamphetamine (MDMA or Ecstasy).
PG  - 922-7
AB  - OBJECTIVE(S): 3,4-Methylenedioxymethamphetamine (MDMA) is one of the most popular 
      drugs of abuse in the world with hallucinogenic properties that has been shown to 
      induce apoptosis in liver cells. The present study aimed to investigate the 
      effects of pentoxifylline (PTX) on liver damage induced by acute administration 
      of MDMA in Wistar rat. MATERIALS AND METHODS: Animals were administered with 
      saline or MDMA (7.5 mg/kg, IP) 3 times with 2 hr intervals. PTX (200 mg kg, IP), 
      was administered simultaneously with last injection of MDMA in experimental 
      group. RESULTS: The concomitant administration of pentoxifylline and MDMA 
      decreased liver injury including apoptosis, fibrosis and hepatocytes damages. 
      CONCLUSION: Our results showed for the first time that PTX treatment diminishes 
      the extent of apoptosis and fibrosis caused by MDMA in rat liver.
FAU - Movassaghi, Shabnam
AU  - Movassaghi S
AD  - Department of Anatomy, Islamic Azad University Tehran Medical Branch, Tehran, 
      Iran.
FAU - Nadia Sharifi, Zahra
AU  - Nadia Sharifi Z
FAU - Mohammadzadeh, Farzaneh
AU  - Mohammadzadeh F
FAU - Soleimani, Mansooreh
AU  - Soleimani M
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Iran J Basic Med Sci
JT  - Iranian journal of basic medical sciences
JID - 101517966
PMC - PMC3786105
OTO - NOTNLM
OT  - Apoptosis
OT  - Fibrosis
OT  - Liver
OT  - MDMA
OT  - Pentoxifylline
EDAT- 2013/10/10 06:00
MHDA- 2013/10/10 06:01
PMCR- 2013/08/01
CRDT- 2013/10/10 06:00
PHST- 2012/12/10 00:00 [received]
PHST- 2013/01/30 00:00 [accepted]
PHST- 2013/10/10 06:00 [entrez]
PHST- 2013/10/10 06:00 [pubmed]
PHST- 2013/10/10 06:01 [medline]
PHST- 2013/08/01 00:00 [pmc-release]
AID - ijbms-16-922 [pii]
PST - ppublish
SO  - Iran J Basic Med Sci. 2013 Aug;16(8):922-7.