PMID- 24106968
OWN - NLM
STAT- MEDLINE
DCOM- 20140605
LR  - 20191027
IS  - 1875-5550 (Electronic)
IS  - 1389-2037 (Linking)
VI  - 14
IP  - 7
DP  - 2013 Nov
TI  - Functional switch from pro-neurotrophins to mature neurotrophins.
PG  - 617-25
AB  - Growing evidence has shown that the proforms of several neurotrophins, e.g., 
      nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), 
      neurotrophin3 (NT3) can be synthesized, secreted from neurons or glial cells and 
      function actively in mammalian nervous system. By the intracellular and 
      extracellular enzymatic cleavage processing, mature neurotrophins are generated 
      and exert their functions in the developing, physiological and pathological 
      activities. While mature neurotrophins exhibit neuroprotective roles via tyrosine 
      kinase receptors (TrkA, TrkB and TrkC), the proforms of neurotrophins show 
      totally-different biological effects that may induce apoptotic cell death of 
      neurons by triggering p75NTR-sortilin signaling cascades. In addition, another 
      key neurotrophic factor named glial-derived neurotrophic factor (GDNF) also 
      appears to be a product generated from proGDNF, and its cleavage and potential 
      biological function of proGDNF remains an unrevealed problem. Obviously, 
      accumulating studies indicated that the exact or timely cleavage processing 
      should be essential for the functional switch from proneurotrophins to mature 
      neurotrophins, while dysfunction in the enzymatic cleavage, aberrant 
      extracellular release, and abnormal subunit organization of binding receptors 
      might be also crucially involved in neurodegeneration of the central neurons, 
      pathogenesis, and even disease progression of various neurodegenerative diseases 
      in human beings.
FAU - Sun, Xiao-Long
AU  - Sun XL
AD  - Institute of Neurosciences, The Fourth Military Medical University, Xi'an, 
      710032, China. lwchen@fmmu.edu.cn.
FAU - Chen, Bei-Yu
AU  - Chen BY
FAU - Xia, Yi
AU  - Xia Y
FAU - Wang, Jing-Jie
AU  - Wang JJ
FAU - Chen, Liang-Wei
AU  - Chen LW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - Curr Protein Pept Sci
JT  - Current protein & peptide science
JID - 100960529
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Protein Precursors)
SB  - IM
MH  - Animals
MH  - Disease
MH  - Humans
MH  - Nerve Growth Factors/*metabolism
MH  - Protein Precursors/metabolism
MH  - Signal Transduction
EDAT- 2013/10/11 06:00
MHDA- 2014/06/06 06:00
CRDT- 2013/10/11 06:00
PHST- 2012/07/11 00:00 [received]
PHST- 2013/08/16 00:00 [revised]
PHST- 2013/08/16 00:00 [accepted]
PHST- 2013/10/11 06:00 [entrez]
PHST- 2013/10/11 06:00 [pubmed]
PHST- 2014/06/06 06:00 [medline]
AID - CPPS-EPUB-56588 [pii]
AID - 10.2174/1389203711209070658 [doi]
PST - ppublish
SO  - Curr Protein Pept Sci. 2013 Nov;14(7):617-25. doi: 10.2174/1389203711209070658.