PMID- 24107080
OWN - NLM
STAT- MEDLINE
DCOM- 20140207
LR  - 20210215
IS  - 1365-3083 (Electronic)
IS  - 0300-9475 (Linking)
VI  - 78
IP  - 6
DP  - 2013 Dec
TI  - The expression and significance of TIPE2 in peripheral blood mononuclear cells 
      from asthmatic children.
PG  - 523-8
LID - 10.1111/sji.12110 [doi]
AB  - Tumour necrosis factor-alpha-induced protein-8 like-2 (TIPE2) is a newly identified 
      immune negative regulator. The abnormal expression of TIPE2 has been found in 
      several human inflammatory diseases. However, the expression level and clinical 
      significance of TIPE2 in childhood asthma remain unclear. In this study, we 
      detected TIPE2 expression in peripheral blood mononuclear cells (PBMC) from 42 
      children with asthma and 39 healthy controls by RT-PCR, qRT-PCR and Western blot. 
      We also detected the levels of serum total immunoglobulin E (IgE), eosinophil 
      (EO), interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) and analysed the correlations 
      of TIPE2 expression with IgE, EO, IL-4 and IFN-gamma. The results showed that TIPE2 
      mRNA and protein expression were decreased in children with asthma compared with 
      healthy controls. The levels of IgE, EO and IL-4 in the children with asthma were 
      obviously higher than those in normal controls, while the level of IFN-gamma in 
      patients with asthma was significantly lower than that in healthy subjects. 
      Furthermore, the expression level of TIPE2 mRNA was negatively correlated with 
      IgE, EO and IL-4. However, no statistically significant correlation was found 
      between TIPE2 mRNA expression and serum IFN-gamma level. In conclusion, our data 
      suggest that reduced TIPE2 expression may contribute to the pathogenesis of 
      childhood asthma.
CI  - (c) 2013 John Wiley & Sons Ltd.
FAU - Ma, Y
AU  - Ma Y
AD  - Institute of Immunology, Shandong University School of Medicine, Jinan, Shandong, 
      China.
FAU - Liu, X
AU  - Liu X
FAU - Wei, Z
AU  - Wei Z
FAU - Wang, X
AU  - Wang X
FAU - Wang, Z
AU  - Wang Z
FAU - Zhong, W
AU  - Zhong W
FAU - Li, Y
AU  - Li Y
FAU - Zhu, F
AU  - Zhu F
FAU - Guo, C
AU  - Guo C
FAU - Zhang, L
AU  - Zhang L
FAU - Wang, X
AU  - Wang X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Scand J Immunol
JT  - Scandinavian journal of immunology
JID - 0323767
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (TNFAIP8L2 protein, human)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Asthma/blood/immunology/*metabolism
MH  - Child
MH  - Child, Preschool
MH  - Eosinophils/cytology
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Infant
MH  - Interferon-gamma/blood
MH  - Interleukin-4/blood
MH  - Intracellular Signaling Peptides and Proteins/biosynthesis/genetics/*metabolism
MH  - Leukocyte Count
MH  - Leukocytes, Mononuclear/immunology/*metabolism
MH  - Male
MH  - RNA, Messenger/biosynthesis
EDAT- 2013/10/11 06:00
MHDA- 2014/02/08 06:00
CRDT- 2013/10/11 06:00
PHST- 2013/05/28 00:00 [received]
PHST- 2013/09/05 00:00 [accepted]
PHST- 2013/10/11 06:00 [entrez]
PHST- 2013/10/11 06:00 [pubmed]
PHST- 2014/02/08 06:00 [medline]
AID - 10.1111/sji.12110 [doi]
PST - ppublish
SO  - Scand J Immunol. 2013 Dec;78(6):523-8. doi: 10.1111/sji.12110.