PMID- 24107311
OWN - NLM
STAT- MEDLINE
DCOM- 20140806
LR  - 20220311
IS  - 1096-1208 (Electronic)
IS  - 0882-4010 (Linking)
VI  - 65
DP  - 2013 Dec
TI  - Regulatory T cells in cutaneous lesions of patients with Paracoccidioidomycosis.
PG  - 36-40
LID - S0882-4010(13)00123-X [pii]
LID - 10.1016/j.micpath.2013.09.004 [doi]
AB  - Paracoccidioidomycosis (PCM) is a systemic mycosis caused by the dimorphic fungus 
      Paracoccidioides brasiliensis, with high incidence in Brazil and very significant 
      in Latin America. The disease is clinically classified as acute, subacute or 
      chronic where the primary lesion initiates in the lungs and can spread to other 
      organs such as the skin and mucous membranes. The lesions are characterized by 
      granulomatous formation, organized according to the type of pattern of host 
      immune response. We demonstrated and quantified by immunohistochemistry the 
      expression of Foxp3, CD25, TGF-beta and IL-10 in thirty cutaneous lesions with 
      different presentation of granulomatous response. Cells expressing Foxp3 and CD25 
      were increased in lesions with compact granulomas. The expression of TGF-beta and 
      IL-10 was similar in all PCM lesions. As previous studies, our data suggest the 
      correlation of Treg cells with the chronicity of the disease and the 
      participation in suppressing mechanism as a possible source of IL-10. TGF-beta and 
      IL-10, two important suppressor cytokines, are expressed in great amounts in the 
      lesions but our results do not allow correlating with the differences in the 
      granulomatous response.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Silva, Aline Alves de Lima
AU  - Silva AA
AD  - Laboratorio da Disciplina de Patologia de Molestias Transmissiveis, Departamento 
      de Patologia, Faculdade de Medicina da Universidade de Sao Paulo, Brazil; 
      Laboratorio de Dermatopatologia, Departamento de Dermatologia, Faculdade de 
      Medicina da Universidade de Sao Paulo, Brazil.
FAU - Sotto, Mirian N
AU  - Sotto MN
FAU - Duarte, Maria Irma Seixas
AU  - Duarte MI
FAU - Pagliari, Carla
AU  - Pagliari C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131006
PL  - England
TA  - Microb Pathog
JT  - Microbial pathogenesis
JID - 8606191
RN  - 0 (Antigens, Fungal)
RN  - 0 (FOXP3 protein, human)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (IL10 protein, human)
RN  - 0 (IL2RA protein, human)
RN  - 0 (Interleukin-2 Receptor alpha Subunit)
RN  - 0 (Transforming Growth Factor beta)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Adult
MH  - Antigens, Fungal/immunology
MH  - Female
MH  - Forkhead Transcription Factors/immunology
MH  - Granuloma/immunology/microbiology
MH  - Humans
MH  - Hypersensitivity, Delayed/immunology
MH  - Interleukin-10/immunology
MH  - Interleukin-2 Receptor alpha Subunit/immunology
MH  - Male
MH  - Mucous Membrane/immunology/microbiology/pathology
MH  - Paracoccidioides/*immunology
MH  - Paracoccidioidomycosis/*immunology/microbiology
MH  - Skin/*immunology/microbiology/pathology
MH  - T-Lymphocytes, Regulatory/*immunology
MH  - Transforming Growth Factor beta/immunology
OTO - NOTNLM
OT  - Cytokines
OT  - Paracoccidioidomycosis
OT  - Regulatory T cells
OT  - Skin
EDAT- 2013/10/11 06:00
MHDA- 2014/08/07 06:00
CRDT- 2013/10/11 06:00
PHST- 2013/06/12 00:00 [received]
PHST- 2013/09/17 00:00 [revised]
PHST- 2013/09/18 00:00 [accepted]
PHST- 2013/10/11 06:00 [entrez]
PHST- 2013/10/11 06:00 [pubmed]
PHST- 2014/08/07 06:00 [medline]
AID - S0882-4010(13)00123-X [pii]
AID - 10.1016/j.micpath.2013.09.004 [doi]
PST - ppublish
SO  - Microb Pathog. 2013 Dec;65:36-40. doi: 10.1016/j.micpath.2013.09.004. Epub 2013 
      Oct 6.