PMID- 24107543
OWN - NLM
STAT- MEDLINE
DCOM- 20140626
LR  - 20180816
IS  - 1423-0224 (Electronic)
IS  - 0302-282X (Linking)
VI  - 68
IP  - 3
DP  - 2013
TI  - Genetic influence of COMT and BDNF gene polymorphisms on resilience in healthy 
      college students.
PG  - 174-80
LID - 10.1159/000353257 [doi]
AB  - PURPOSE: Resilience refers to the individual positive capacity to cope with 
      stress and to restore homeostasis, which may be mediated by adaptive 
      neurobiological changes in the brain. We investigated the genetic influence of 
      the catechol-O-methyltransferase (COMT) Val158Met and the brain-derived 
      neurotrophic factor (BDNF) Val66Met for individual differences in resilience in 
      healthy Korean college students. METHODS: A sample of 321 healthy college 
      volunteers (167 males, 154 females) was assessed by genotyping and with the 
      25-item Connor-Davidson Resilience Scale. Two-way analysis of covariance was used 
      to test the association between participants' COMT and BDNF functional 
      polymorphisms and their resilience. RESULTS: A significant main effect of the 
      COMT polymorphism on resilience and a gene-gene interaction effect between the 
      COMT and BDNF on resilience were observed for males. Male subjects with the COMT 
      Met-present genotype had a significantly higher resilience than those with the 
      Val/Val genotype. Among males with the COMT Val/Val genotype, subjects with the 
      homozygous Val allele of the BDNF tended to have lower resilience than the BDNF 
      Met carriers, while among males with the COMT Met-present genotype, those with 
      the homozygous Val allele of the BDNF tended to have higher resilience than BDNF 
      Met carriers. No main or interaction effects of the COMT and BDNF on resilience 
      were observed for females. CONCLUSION: These findings suggest the effects of COMT 
      Val158Met polymorphism on resilience could be modulated by BDNF Val66Met 
      polymorphism in males.
CI  - (c) 2013 S. Karger AG, Basel.
FAU - Kang, Jee In
AU  - Kang JI
AD  - Department of Psychiatry and Institute of Behavioral Science in Medicine, Yonsei 
      University College of Medicine, Seoul, South Korea.
FAU - Kim, Se Joo
AU  - Kim SJ
FAU - Song, Yun Young
AU  - Song YY
FAU - Namkoong, Kee
AU  - Namkoong K
FAU - An, Suk Kyoon
AU  - An SK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130930
PL  - Switzerland
TA  - Neuropsychobiology
JT  - Neuropsychobiology
JID - 7512895
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - EC 2.1.1.6 (COMT protein, human)
RN  - EC 2.1.1.6 (Catechol O-Methyltransferase)
SB  - IM
MH  - Adaptation, Psychological/*physiology
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Catechol O-Methyltransferase/*genetics
MH  - Female
MH  - Humans
MH  - Male
MH  - *Polymorphism, Genetic
MH  - *Resilience, Psychological
MH  - Stress, Psychological/*genetics
MH  - Young Adult
EDAT- 2013/10/11 06:00
MHDA- 2014/06/27 06:00
CRDT- 2013/10/11 06:00
PHST- 2012/08/17 00:00 [received]
PHST- 2013/05/27 00:00 [accepted]
PHST- 2013/10/11 06:00 [entrez]
PHST- 2013/10/11 06:00 [pubmed]
PHST- 2014/06/27 06:00 [medline]
AID - 000353257 [pii]
AID - 10.1159/000353257 [doi]
PST - ppublish
SO  - Neuropsychobiology. 2013;68(3):174-80. doi: 10.1159/000353257. Epub 2013 Sep 30.