PMID- 24107715
OWN - NLM
STAT- MEDLINE
DCOM- 20140620
LR  - 20190212
IS  - 1421-9778 (Electronic)
IS  - 1015-8987 (Linking)
VI  - 32
IP  - 4
DP  - 2013
TI  - Kruppel-like factor 2 regulates dendritic cell activation in patients with acute 
      coronary syndrome.
PG  - 931-41
LID - 10.1159/000354496 [doi]
AB  - OBJECTIVE: Dendritic cells (DCs) activation is important in atherosclerosis and 
      coronary heart disease, but the mechanisms regulating activation of dendritic 
      cells remain largely unclear. The aim of this study was to evaluate the effect of 
      transcription factor Kruppel-like factor 2 (KLF2) in the proinflammatory 
      activation of DCs in acute coronary syndrome. METHODS AND RESULTS: In this study, 
      the expression of CD80 and KLF2 was detected in DCs in normal health controls, 
      patients with stable angina (SA), and acute coronary syndrome (ACS). Our study 
      found that compared with normal control and SA, KLF2 expression in DCs is reduced 
      in patients with ACS. Moreover, the surface expression of CD80 was increased in 
      ACS. In vitro experiment, we found that ox-LDL could increase CD80 expression and 
      decrease KLF2 expression. Furthermore, down-regulated KLF2 could in turn increase 
      CD80 expression via NF-kappaB pathway. CONCLUSIONS: These observations identify KLF2 
      as a novel negative regulator of DC function and it may play an essential role in 
      DC activation in ACS.
CI  - (c) 2013 S. Karger AG, Basel
FAU - Fang, Hongcheng
AU  - Fang H
AD  - Department of Cardiology, Shenzhen Sixth People's Hospital (Nanshan Hospital), 
      Huazhong University of Science and Technology, Union Shenzhen Hospital, Shenzhen, 
      China.
FAU - Lin, Jing
AU  - Lin J
FAU - Wang, Lei
AU  - Wang L
FAU - Xie, Peiyi
AU  - Xie P
FAU - Wang, Xiaoyan
AU  - Wang X
FAU - Fu, Jianyun
AU  - Fu J
FAU - Ai, Wen
AU  - Ai W
FAU - Chen, Shaoyuan
AU  - Chen S
FAU - Chen, Fei
AU  - Chen F
FAU - Zhang, Fengxiao
AU  - Zhang F
FAU - Su, Yousu
AU  - Su Y
FAU - Li, Dazhu
AU  - Li D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131001
PL  - Germany
TA  - Cell Physiol Biochem
JT  - Cellular physiology and biochemistry : international journal of experimental 
      cellular physiology, biochemistry, and pharmacology
JID - 9113221
RN  - 0 (B7-1 Antigen)
RN  - 0 (KLF2 protein, human)
RN  - 0 (Kruppel-Like Transcription Factors)
RN  - 0 (NF-kappa B)
SB  - IM
MH  - Acute Coronary Syndrome/genetics/*metabolism
MH  - Adult
MH  - Aged
MH  - B7-1 Antigen/metabolism
MH  - Blotting, Western
MH  - Cells, Cultured
MH  - Dendritic Cells/*metabolism
MH  - Electrophoretic Mobility Shift Assay
MH  - Female
MH  - Humans
MH  - Kruppel-Like Transcription Factors/genetics/*metabolism
MH  - Male
MH  - Middle Aged
MH  - NF-kappa B/*metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Signal Transduction
EDAT- 2013/10/11 06:00
MHDA- 2014/06/21 06:00
CRDT- 2013/10/11 06:00
PHST- 2013/09/01 00:00 [accepted]
PHST- 2013/10/11 06:00 [entrez]
PHST- 2013/10/11 06:00 [pubmed]
PHST- 2014/06/21 06:00 [medline]
AID - 000354496 [pii]
AID - 10.1159/000354496 [doi]
PST - ppublish
SO  - Cell Physiol Biochem. 2013;32(4):931-41. doi: 10.1159/000354496. Epub 2013 Oct 1.