PMID- 24108795
OWN - NLM
STAT- MEDLINE
DCOM- 20140811
LR  - 20140102
IS  - 1522-1598 (Electronic)
IS  - 0022-3077 (Linking)
VI  - 111
IP  - 1
DP  - 2014 Jan
TI  - Effects of the motor cortical quadripulse transcranial magnetic stimulation (QPS) 
      on the contralateral motor cortex and interhemispheric interactions.
PG  - 26-35
LID - 10.1152/jn.00515.2013 [doi]
AB  - Corpus callosum connects the bilateral primary motor cortices (M1s) and plays an 
      important role in motor control. Using the paired-pulse transcranial magnetic 
      stimulation (TMS) paradigm, we can measure interhemispheric inhibition (IHI) and 
      interhemispheric facilitation (IHF) as indexes of the interhemispheric 
      interactions in humans. We investigated how quadripulse transcranial magnetic 
      stimulation (QPS), one form of repetitive TMS (rTMS), on M1 affects the 
      contralateral M1 and the interhemispheric interactions. QPS is able to induce 
      bidirectional plastic changes in M1 depending on the interstimulus intervals 
      (ISIs) of TMS pulses: long-term potentiation (LTP)-like effect by QPS-5 protocol, 
      and long-term depression-like effect by QPS-50, whose numbers indicate the ISI 
      (ms). Twelve healthy subjects were enrolled. We applied QPS over the left M1 and 
      recorded several parameters before and 30 min after QPS. QPS-5, which increased 
      motor-evoked potentials (MEPs) induced by left M1 activation, also increased MEPs 
      induced by right M1 activation. Meanwhile, QPS-50, which decreased MEPs elicited 
      by left M1 activation, did not induce any significant changes in MEPs elicited by 
      right M1 activation. None of the resting motor threshold, active motor threshold, 
      short-interval intracortical inhibition, long-interval intracortical inhibition, 
      intracortical facilitation, and short-interval intracortical inhibition in right 
      M1 were affected by QPS. IHI and IHF from left to right M1 significantly 
      increased after left M1 QPS-5. The degree of left first dorsal interosseous MEP 
      amplitude change by QPS-5 significantly correlated with the degree of IHF change. 
      We suppose that the LTP-like effect on the contralateral M1 may be produced by 
      some interhemispheric interactions through the corpus callosum.
FAU - Tsutsumi, Ryosuke
AU  - Tsutsumi R
AD  - Department of Neurology, Division of Neuroscience, Graduate School of Medicine, 
      The University of Tokyo, Tokyo, Japan; and.
FAU - Hanajima, Ritsuko
AU  - Hanajima R
FAU - Terao, Yasuo
AU  - Terao Y
FAU - Shirota, Yuichiro
AU  - Shirota Y
FAU - Ohminami, Shinya
AU  - Ohminami S
FAU - Shimizu, Takahiro
AU  - Shimizu T
FAU - Tanaka, Nobuyuki
AU  - Tanaka N
FAU - Ugawa, Yoshikazu
AU  - Ugawa Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131009
PL  - United States
TA  - J Neurophysiol
JT  - Journal of neurophysiology
JID - 0375404
SB  - IM
MH  - Adult
MH  - Corpus Callosum/physiology
MH  - Evoked Potentials, Motor
MH  - Female
MH  - *Functional Laterality
MH  - Humans
MH  - Long-Term Potentiation
MH  - Male
MH  - Motor Cortex/*physiology
MH  - Neural Inhibition
MH  - *Transcranial Magnetic Stimulation
OTO - NOTNLM
OT  - corpus callosum
OT  - interhemispheric facilitation
OT  - interhemispheric inhibition
OT  - plasticity
OT  - repetitive transcranial magnetic stimulation
EDAT- 2013/10/11 06:00
MHDA- 2014/08/12 06:00
CRDT- 2013/10/11 06:00
PHST- 2013/10/11 06:00 [entrez]
PHST- 2013/10/11 06:00 [pubmed]
PHST- 2014/08/12 06:00 [medline]
AID - jn.00515.2013 [pii]
AID - 10.1152/jn.00515.2013 [doi]
PST - ppublish
SO  - J Neurophysiol. 2014 Jan;111(1):26-35. doi: 10.1152/jn.00515.2013. Epub 2013 Oct 
      9.