PMID- 24110051
OWN - NLM
STAT- MEDLINE
DCOM- 20150810
LR  - 20200928
IS  - 2694-0604 (Electronic)
IS  - 2375-7477 (Linking)
VI  - 2013
DP  - 2013
TI  - A novel approach for deriving global activation maps from non-averaged cardiac 
      optical signals.
PG  - 1772-5
LID - 10.1109/EMBC.2013.6609864 [doi]
AB  - Cardiac arrhythmias are often characterized by non-repetitive complex activation 
      sequences. The properties of electrical activity in cardiac tissue, such as 
      activation time (AT), can be accurately determined using optical imaging of 
      electrical signals using voltage-sensitive dyes. The electrical AT of optical 
      action potentials is known to accurately correlate with the time of the maximal 
      derivative (dF/dt(max)) of the upstroke of ensemble averaged optical signals. The 
      sensitivity of dF/dt(max) to noise is therefore problematic for mapping AT from 
      nonrepetitive activity. Here we experimentally evaluated a novel method to 
      determine activation times (AT) from non-averaged epicardial optical signals. The 
      method depends upon the time delays of activation between adjacent pixels 
      developing a global AT map, as opposed to measuring local AT from each pixel 
      independently based on dF/dt(max). ATs from dF/dt(max) and global AT maps of 
      non-ensemble averaged signals were correlated with averaged signals. Global ATs 
      improved linear correlation coefficients and accuracy of AT patterns. 
      Furthermore, global AT maps were significantly more robust at reproducing AT maps 
      between consecutive stable beats. The proposed method of global AT mapping will 
      potentially enable accurate mapping of non-repetitive propagation during 
      arrhythmias.
FAU - Walton, Richard D
AU  - Walton RD
FAU - Bernus, Olivier
AU  - Bernus O
FAU - Dubois, Remi
AU  - Dubois R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Annu Int Conf IEEE Eng Med Biol Soc
JT  - Annual International Conference of the IEEE Engineering in Medicine and Biology 
      Society. IEEE Engineering in Medicine and Biology Society. Annual International 
      Conference
JID - 101763872
SB  - IM
MH  - Action Potentials
MH  - Animals
MH  - Heart/*physiology
MH  - Male
MH  - Myocardial Contraction
MH  - Optical Imaging
MH  - Rats, Wistar
EDAT- 2013/10/11 06:00
MHDA- 2015/08/11 06:00
CRDT- 2013/10/11 06:00
PHST- 2013/10/11 06:00 [entrez]
PHST- 2013/10/11 06:00 [pubmed]
PHST- 2015/08/11 06:00 [medline]
AID - 10.1109/EMBC.2013.6609864 [doi]
PST - ppublish
SO  - Annu Int Conf IEEE Eng Med Biol Soc. 2013;2013:1772-5. doi: 
      10.1109/EMBC.2013.6609864.