PMID- 24110999
OWN - NLM
STAT- MEDLINE
DCOM- 20150716
LR  - 20200928
IS  - 2694-0604 (Electronic)
IS  - 2375-7477 (Linking)
VI  - 2013
DP  - 2013
TI  - Heart rate complexity and cardiac sympathetic dysinnervation in patients with 
      type 2 diabetes mellitus.
PG  - 5570-3
LID - 10.1109/EMBC.2013.6610812 [doi]
AB  - Cardiovascular autonomic neuropathy (CAN) is one of the most severe complications 
      of type 2 diabetes mellitus (T2DM). The aim of this study was to investigate 
      associations of cardiac sympathetic dysinnervation (CSD; by (123)I-MIBG 
      scintigraphy) with short-term heart rate variability (HRV) measured by 
      traditional vs. complexity markers. ECG was measured in 31 diabetic patients 
      during rest over a period of 5 minutes and HRV quantified in different domains 
      (time and frequency domain, scaling properties, symbolic dynamics). (123)I-MIBG 
      scintigraphy identified 16 patients with CSD. Resting heart rate was increased 
      and HRV reduced in these patients. In a subgroup of 16 patients ECG was also 
      measured during standing. Changes in several HRV measures upon standing 
      demonstrated cardiac responsiveness to orthostatic stress. Strong correlations 
      between HRV, measured during standing, and CSD were observed with metrics based 
      on symbolic dynamics. In conclusion, HRV assessment during standing may be useful 
      for assessing cardiac sympathetic dysinnervation in patients with type 2 diabetes 
      mellitus.
FAU - Baumert, Mathias
AU  - Baumert M
FAU - Sacre, Julian W
AU  - Sacre JW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Annu Int Conf IEEE Eng Med Biol Soc
JT  - Annual International Conference of the IEEE Engineering in Medicine and Biology 
      Society. IEEE Engineering in Medicine and Biology Society. Annual International 
      Conference
JID - 101763872
RN  - 35MRW7B4AD (3-Iodobenzylguanidine)
SB  - IM
MH  - 3-Iodobenzylguanidine
MH  - Diabetes Mellitus, Type 2/complications/diagnostic imaging/*physiopathology
MH  - Diabetic Neuropathies/complications/*physiopathology
MH  - Heart/diagnostic imaging/*physiopathology
MH  - Heart Rate/*physiology
MH  - Humans
MH  - Radionuclide Imaging
MH  - Supine Position
MH  - Sympathetic Nervous System/diagnostic imaging/*physiopathology
EDAT- 2013/10/11 06:00
MHDA- 2015/07/17 06:00
CRDT- 2013/10/11 06:00
PHST- 2013/10/11 06:00 [entrez]
PHST- 2013/10/11 06:00 [pubmed]
PHST- 2015/07/17 06:00 [medline]
AID - 10.1109/EMBC.2013.6610812 [doi]
PST - ppublish
SO  - Annu Int Conf IEEE Eng Med Biol Soc. 2013;2013:5570-3. doi: 
      10.1109/EMBC.2013.6610812.