PMID- 24112788
OWN - NLM
STAT- MEDLINE
DCOM- 20140929
LR  - 20220309
IS  - 1558-1497 (Electronic)
IS  - 0197-4580 (Linking)
VI  - 35
IP  - 4
DP  - 2014 Apr
TI  - Increased pro-nerve growth factor and decreased brain-derived neurotrophic factor 
      in non-Alzheimer's disease tauopathies.
PG  - 926-33
LID - S0197-4580(13)00374-6 [pii]
LID - 10.1016/j.neurobiolaging.2013.08.029 [doi]
AB  - Alterations in the expression and signaling of brain-derived neurotrophic factor 
      (BDNF) and the precursor to nerve growth factor (NGF), proNGF, play a role in the 
      neuronal and cognitive dysfunction of Alzheimer's disease. Aggregated amyloid-beta 
      has been shown to down-regulate specific BDNF transcripts in Alzheimer's disease, 
      but the role of tau pathology in neurotrophin dysregulation has not been 
      investigated. We measured levels of BDNF mRNA and protein using real-time 
      quantitative reverse transcription-polymerase chain reaction and enzyme-linked 
      immunosorbent assay and proNGF protein using Western blotting in parietal cortex 
      of subjects with tauopathies, neurodegenerative diseases exhibiting tau pathology 
      without amyloid-beta accumulation. We observed a significant increase in the level 
      of proNGF protein in Pick's disease and a significant decrease in BDNF mRNA and 
      protein levels in Pick's disease and corticobasal degeneration, but no 
      neurotrophin alterations in progressive supranuclear palsy. The decrease in total 
      BDNF mRNA levels in these tauopathies was predominantly due to down-regulation of 
      transcript IV. These findings implicate tau pathology in neurotrophin 
      dysregulation, which may represent a mechanism through which tau confers toxicity 
      in Alzheimer's disease and related non-Alzheimer's dementias.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Belrose, Jillian C
AU  - Belrose JC
AD  - Department of Psychiatry and Behavioural Neurosciences, McMaster University, 
      Hamilton, Ontario, Canada.
FAU - Masoudi, Raheleh
AU  - Masoudi R
AD  - Department of Biology, McMaster University, Hamilton, Ontario, Canada.
FAU - Michalski, Bernadeta
AU  - Michalski B
AD  - Department of Psychiatry and Behavioural Neurosciences, McMaster University, 
      Hamilton, Ontario, Canada.
FAU - Fahnestock, Margaret
AU  - Fahnestock M
AD  - Department of Psychiatry and Behavioural Neurosciences, McMaster University, 
      Hamilton, Ontario, Canada; Department of Biology, McMaster University, Hamilton, 
      Ontario, Canada. Electronic address: fahnest@mcmaster.ca.
LA  - eng
GR  - MOP-64382/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131008
PL  - United States
TA  - Neurobiol Aging
JT  - Neurobiology of aging
JID - 8100437
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - 0 (tau Proteins)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/genetics/metabolism
MH  - Brain-Derived Neurotrophic Factor/*genetics/*metabolism
MH  - Down-Regulation
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - *Gene Expression
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Growth Factor/*genetics/*metabolism
MH  - Pick Disease of the Brain/genetics/metabolism
MH  - RNA, Messenger/metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Tauopathies/*genetics/*metabolism
MH  - tau Proteins/*metabolism/*toxicity
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Brain-derived neurotrophic factor
OT  - Corticobasal degeneration
OT  - Nerve growth factor
OT  - Neurotrophin
OT  - Pick's disease
OT  - Post mortem brain
OT  - Progressive supranuclear palsy
OT  - Tau
OT  - Tauopathy
EDAT- 2013/10/12 06:00
MHDA- 2014/09/30 06:00
CRDT- 2013/10/12 06:00
PHST- 2013/01/26 00:00 [received]
PHST- 2013/08/23 00:00 [revised]
PHST- 2013/08/23 00:00 [accepted]
PHST- 2013/10/12 06:00 [entrez]
PHST- 2013/10/12 06:00 [pubmed]
PHST- 2014/09/30 06:00 [medline]
AID - S0197-4580(13)00374-6 [pii]
AID - 10.1016/j.neurobiolaging.2013.08.029 [doi]
PST - ppublish
SO  - Neurobiol Aging. 2014 Apr;35(4):926-33. doi: 
      10.1016/j.neurobiolaging.2013.08.029. Epub 2013 Oct 8.