PMID- 24112874 OWN - NLM STAT- MEDLINE DCOM- 20140731 LR - 20200418 IS - 1873-3360 (Electronic) IS - 0306-4530 (Linking) VI - 39 DP - 2014 Jan TI - Brain Derived Neurotrophic Factor (BDNF) levels as a possible predictor of psychopathology in healthy twins at high and low risk for affective disorder. PG - 179-183 LID - S0306-4530(13)00326-0 [pii] LID - 10.1016/j.psyneuen.2013.09.007 [doi] AB - Brain Derived Neurotrophic Factor (BDNF) is a potential biomarker of affective disorder. However, longitudinal studies evaluating a potential predictive role of BDNF on subsequent psychopathology are lacking. The aim of this study was to investigate whether BDNF alone or in interaction with the BDNF Val66Met polymorphism predict onset of affective disorder in healthy individuals at heritable risk for affective disorder. In a high-risk study, we assessed whole blood levels of BDNF in 234 healthy monozygotic and dizygotic twins with or without a co-twin history of affective disorder (high and low risk twins, respectively). Participants were followed up longitudinally with questionnaires at 6-month intervals for mean seven years and then reassessed with a personal interview to obtain information about whether they had developed psychiatric illness. At follow-up 36 participants (15.4%) had developed psychiatric disorder. Cox regression analysis revealed that BDNF levels at baseline were not associated with onset of illness in this explorative study. Further, two-way interactions between BDNF levels and the Val66Met polymorphism or between familial risk and the Val66Met polymorphism did not predict illness onset. CI - Copyright (c) 2013 Elsevier Ltd. All rights reserved. FAU - Vinberg, Maj AU - Vinberg M AD - Psychiatric Centre Copenhagen, Rigshospitalet, University Hospital of Copenhagen, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. Electronic address: maj.vinberg@regionh.dk. FAU - Miskowiak, Kamilla AU - Miskowiak K AD - Psychiatric Centre Copenhagen, Rigshospitalet, University Hospital of Copenhagen, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. Electronic address: kamilla.miskowiak@regionh.dk. FAU - Kessing, Lars Vedel AU - Kessing LV AD - Psychiatric Centre Copenhagen, Rigshospitalet, University Hospital of Copenhagen, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. Electronic address: lars.vedel.kessing@regionh.dk. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20130917 PL - England TA - Psychoneuroendocrinology JT - Psychoneuroendocrinology JID - 7612148 RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Adult MH - Brain-Derived Neurotrophic Factor/*blood/genetics MH - Diseases in Twins/*blood/genetics MH - Female MH - *Genetic Predisposition to Disease MH - Genotype MH - Humans MH - Life Change Events MH - Male MH - Middle Aged MH - Mood Disorders/*blood/genetics MH - Polymorphism, Single Nucleotide MH - Risk Factors MH - Twins, Dizygotic/genetics/psychology MH - Twins, Monozygotic/genetics/psychology OTO - NOTNLM OT - BDNF OT - Familiar risk OT - Mood disorders OT - Risk factors OT - The BDNF Val66Met polymorphism EDAT- 2013/10/12 06:00 MHDA- 2014/08/01 06:00 CRDT- 2013/10/12 06:00 PHST- 2013/08/14 00:00 [received] PHST- 2013/09/09 00:00 [accepted] PHST- 2013/10/12 06:00 [entrez] PHST- 2013/10/12 06:00 [pubmed] PHST- 2014/08/01 06:00 [medline] AID - S0306-4530(13)00326-0 [pii] AID - 10.1016/j.psyneuen.2013.09.007 [doi] PST - ppublish SO - Psychoneuroendocrinology. 2014 Jan;39:179-183. doi: 10.1016/j.psyneuen.2013.09.007. Epub 2013 Sep 17.