PMID- 24112897
OWN - NLM
STAT- MEDLINE
DCOM- 20140416
LR  - 20131011
IS  - 0072-9752 (Print)
IS  - 0072-9752 (Linking)
VI  - 116
DP  - 2013
TI  - Deep brain stimulation for major depression.
PG  - 235-43
LID - B978-0-444-53497-2.00018-8 [pii]
LID - 10.1016/B978-0-444-53497-2.00018-8 [doi]
AB  - A third of patients suffering from major depression cannot be helped by 
      conventional treatment methods. These patients face reduced quality of life, high 
      risk of suicide, and little hope of recovery. Deep brain stimulation (DBS) is 
      under scientific evaluation as a new treatment option for these 
      treatment-resistant patients. First clinical studies with small samples have been 
      stimulated at the subgenual cingulate gyrus (Cg25/24), the anterior limb of the 
      capsula interna (ALIC), and the nucleus accumbens (NAcc). Long-term 
      antidepressant effects, augmentation of social functioning, and normalization of 
      brain metabolism have been shown in about 50% of patients. Cognitive safety 
      regarding attention, learning, and memory has been reported. Adverse events were 
      wound infection, suicide, and hypomania, amongst others. Larger studies are under 
      way to confirm these preliminary encouraging results. New hypothesis-guided 
      targets (e.g., medial forebrain bundle, habenula) are about to be assessed in 
      clinical trials. The application of DBS for other psychiatric diseases (e.g., 
      bipolar disorder, alcohol dependency, opioid addiction, schizophrenia) is debated 
      and single case studies are under way. Standards are needed for study 
      registration, target selection, patient inclusion and monitoring, and publication 
      of results to guarantee safety for the patients and scientific exchange.
CI  - (c) 2013 Elsevier B.V. All rights reserved.
FAU - Schlaepfer, T E
AU  - Schlaepfer TE
AD  - Brain Stimulation Group, Department of Psychiatry and Psychotherapy, University 
      Hospital Bonn, Bonn, Germany; Departments of Psychiatry and Mental Health, Johns 
      Hopkins University, Baltimore, MD, USA. Electronic address: schlaepf@jhmi.edu.
FAU - Bewernick, B H
AU  - Bewernick BH
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Handb Clin Neurol
JT  - Handbook of clinical neurology
JID - 0166161
SB  - IM
MH  - Deep Brain Stimulation/*methods
MH  - Depressive Disorder, Major/*therapy
MH  - Humans
OTO - NOTNLM
OT  - anterior limb of internal capsule
OT  - deep brain stimulation
OT  - ethical standards
OT  - major depression
OT  - medial forebrain bundle
OT  - neuromodulation
OT  - nucleus accumbens
OT  - reward system
OT  - subgenual cingulate gyrus
EDAT- 2013/10/12 06:00
MHDA- 2014/04/17 06:00
CRDT- 2013/10/12 06:00
PHST- 2013/10/12 06:00 [entrez]
PHST- 2013/10/12 06:00 [pubmed]
PHST- 2014/04/17 06:00 [medline]
AID - B978-0-444-53497-2.00018-8 [pii]
AID - 10.1016/B978-0-444-53497-2.00018-8 [doi]
PST - ppublish
SO  - Handb Clin Neurol. 2013;116:235-43. doi: 10.1016/B978-0-444-53497-2.00018-8.