PMID- 24113043
OWN - NLM
STAT- MEDLINE
DCOM- 20140814
LR  - 20131011
IS  - 0253-3758 (Print)
IS  - 0253-3758 (Linking)
VI  - 41
IP  - 6
DP  - 2013 Jun
TI  - [Value of cardiopulmonary exercise test in assessment of cardiac function of 
      patients with pulmonary hypertension].
PG  - 497-500
AB  - OBJECTIVE: To explore the role of peak oxygen consumption in assessment of heart 
      function of patients with pulmonary hypertension. METHODS: From September 2010 to 
      April 2012, 101 patients [29 male, mean age: (32.6 +/- 11.4 )years] with pulmonary 
      hypertension diagnosis by right heart catheterization were enrolled. Correlations 
      among peak oxygen consumption, New York Heart Association (NYHA) class, 
      NT-proBNP, 6 minute walking distance (6MWD) and cardiac index are analyzed. 
      RESULTS: There were 44 cases with NYHA class II (43.6%), 49 cases with NYHA class 
      III (48.5%), mean 6MWD was (421 +/- 91 )m, NT-proBNP was (1262 +/- 816) ng/L, 
      pulmonary vascular resistance was (1031 +/- 582) dyn.s(-1).cm(-5), CI was (3.5 +/- 
      2.3) L.min(-1).m(-2), peak oxygen consumption was( 13.8 +/- 4.1)ml.min(-1).kg(-1). 
      6MWD, pulmonary vascular resistance and peak oxygen consumption were related to 
      CI (r = 0.299, -0.541, 0.341, respectively, all P < 0.05), but NYHA class and 
      NT-proBNP were not correlated to CI. Multiple regression analysis demonstrated 
      that peak oxygen consumption (B = 0.135, P = 0.004) but not 6MWD was correlated 
      with CI after adjusting age, sex and pulmonary vascular resistance. ROC analysis 
      found that the sensitivity and specificity using peak oxygen consumption <15.2 
      ml.min(-1).kg(-1) as a cut-off value was 92.6% and 57.5%, respectively, for 
      diagnosing severe heart dysfunction. CONCLUSIONS: The correlation between peak 
      oxygen consumption and CI is better than that of NYHA class, 6MWD, and NT-proBNP 
      with CI. Peak oxygen consumption less than 15.2 ml.min(-1).kg(-1) could be used 
      to detect reduced CI in patients with pulmonary hypertension.
FAU - Luo, Qin
AU  - Luo Q
AD  - State Key Laboratory of Cardiovascalar Disease,Fuwai Hospital,National Center for 
      Cardiovascalar Diseases,Chinese Academy of Medical Sciences and Peking Union 
      Medical College, Beijing 100037, China.
FAU - Liu, Zhi-hong
AU  - Liu ZH
FAU - Ma, Xiu-ping
AU  - Ma XP
FAU - Zhao, Zhi-hui
AU  - Zhao ZH
FAU - Gu, Qing
AU  - Gu Q
FAU - Xiong, Chang-ming
AU  - Xiong CM
FAU - Zhao, Qing
AU  - Zhao Q
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Xin Xue Guan Bing Za Zhi
JT  - Zhonghua xin xue guan bing za zhi
JID - 7910682
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Adult
MH  - *Exercise Test
MH  - Female
MH  - Heart/physiopathology
MH  - Humans
MH  - Hypertension, Pulmonary/*diagnosis/metabolism/physiopathology
MH  - Male
MH  - Natriuretic Peptide, Brain/blood
MH  - Oxygen Consumption
MH  - Peptide Fragments/blood
MH  - Young Adult
EDAT- 2013/10/12 06:00
MHDA- 2014/08/15 06:00
CRDT- 2013/10/12 06:00
PHST- 2013/10/12 06:00 [entrez]
PHST- 2013/10/12 06:00 [pubmed]
PHST- 2014/08/15 06:00 [medline]
PST - ppublish
SO  - Zhonghua Xin Xue Guan Bing Za Zhi. 2013 Jun;41(6):497-500.