PMID- 24113138
OWN - NLM
STAT- MEDLINE
DCOM- 20140205
LR  - 20181202
IS  - 1873-0183 (Electronic)
IS  - 1568-9972 (Linking)
VI  - 13
IP  - 2
DP  - 2014 Feb
TI  - Fms-like tyrosine kinase 3 ligand-dependent dendritic cells in autoimmune 
      inflammation.
PG  - 117-24
LID - S1568-9972(13)00174-2 [pii]
LID - 10.1016/j.autrev.2013.09.010 [doi]
AB  - Dendritic cells (DCs) are specialized in capture, processing and presentation of 
      antigens to T cells. Depending on the type of DC and its activation state, the 
      interaction of DCs with naive T cells can lead to different types of immune 
      response, or to T-cell tolerance. The existence of many specialized subtypes of 
      DCs with particular functions has raised the need to distinguish DCs formed in 
      steady-state from those produced during an inflammatory response. In patients 
      with autoimmune disease and in experimental animal models of autoimmunity, DCs 
      show abnormalities in both numbers and activation state, expressing immunogenic 
      levels of co-stimulatory molecules and pro-inflammatory cytokines. Initial in 
      vitro studies of cytokines in DC development revealed distinct and important 
      roles for the receptor tyrosine kinases, granulocyte-macrophage 
      colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF, 
      also called CSF1) and fms-like tyrosine kinase 3 ligand (Flt3L) in the generation 
      of DCs. Flt3L is critical for instructing DC generation throughout different 
      organs and regulates DC development from Flt3(+) lymphoid and myeloid-committed 
      progenitors to DCs in vivo. The aim of this review is to provide an overview of 
      the role of Flt3L-dependent DCs in the immunopathogenesis of autoimmunity and 
      chronic inflammation and its potential as therapeutic targets.
CI  - (c) 2013 Elsevier B.V. All rights reserved.
FAU - Ramos, M I
AU  - Ramos MI
AD  - Department of Clinical Immunology and Rheumatology, Academic Medical 
      Center/University of Amsterdam, Amsterdam, The Netherlands; Department of 
      Experimental Immunology, Academic Medical Center/University of Amsterdam, 
      Amsterdam, The Netherlands.
FAU - Tak, P P
AU  - Tak PP
FAU - Lebre, M C
AU  - Lebre MC
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20131007
PL  - Netherlands
TA  - Autoimmun Rev
JT  - Autoimmunity reviews
JID - 101128967
RN  - 0 (Cytokines)
RN  - EC 2.7.10.1 (fms-Like Tyrosine Kinase 3)
SB  - IM
MH  - Animals
MH  - Autoimmune Diseases/*immunology/pathology
MH  - Cytokines/immunology
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Immune Tolerance
MH  - Inflammation/immunology/pathology
MH  - T-Lymphocytes/immunology
MH  - fms-Like Tyrosine Kinase 3/*immunology
OTO - NOTNLM
OT  - Autoimmunity
OT  - DC targeting
OT  - DCs
OT  - Inflammation
EDAT- 2013/10/12 06:00
MHDA- 2014/02/06 06:00
CRDT- 2013/10/12 06:00
PHST- 2013/09/20 00:00 [received]
PHST- 2013/09/25 00:00 [accepted]
PHST- 2013/10/12 06:00 [entrez]
PHST- 2013/10/12 06:00 [pubmed]
PHST- 2014/02/06 06:00 [medline]
AID - S1568-9972(13)00174-2 [pii]
AID - 10.1016/j.autrev.2013.09.010 [doi]
PST - ppublish
SO  - Autoimmun Rev. 2014 Feb;13(2):117-24. doi: 10.1016/j.autrev.2013.09.010. Epub 
      2013 Oct 7.