PMID- 24114445
OWN - NLM
STAT- MEDLINE
DCOM- 20140613
LR  - 20131108
IS  - 1869-1889 (Electronic)
IS  - 1674-7305 (Linking)
VI  - 56
IP  - 11
DP  - 2013 Nov
TI  - Frequency of HLA-A 03 associates with HIV-1 infection in a Chinese cohort.
PG  - 1014-9
LID - 10.1007/s11427-013-4555-4 [doi]
AB  - During the early mid-1990s, a number of rural farmers across central China were 
      employed to the unregulated plasmaselling-activity and many of them were infected 
      by HIV-1. However, AIDS progression in the former blood donors (FBDs) is various. 
      The aim of this study is to assess human leukocyte antigen (HLA) class I allele 
      distribution in FBDs and evaluate its association with HIV-1 infection and 
      disease progression. A total of 353 FBDs were enrolled in the cohort including 
      294 ART naive HIV-1 seropositive and 59 HIV-1 seronegative age-matched subjects. 
      The viral load and CD4/CD8 T cell counts were assessed in all subjects. Compared 
      with HIV-seropositive group, the frequency of HLA-A 03 in control was 
      significantly higher. After classifying the HLA-B alleles of the subjects 
      according to the presence of Bw4/Bw6 serological epitopes, detrimental effect of 
      HLA Bw6/ Bw6 homozygosity was also confirmed in the HIV-seropositive subjects. 
      This study provides novel evidence on HLA class I allele distribution and 
      association of HLA-A 03 frequency with HIV-1 infection and viremia in the HIV-1 
      infected FBDs, which may throw light on intervention strategy for the HIV-1 
      infection and our understanding how host immunity and genetic background affect 
      HIV infection and AIDS progression.
FAU - Zhang, Weilun
AU  - Zhang W
AD  - Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking 
      Union Medical College, Beijing, 100005, China.
FAU - Wang, Li
AU  - Wang L
FAU - Hong, Kunxue
AU  - Hong K
FAU - Liu, Yanxin
AU  - Liu Y
FAU - Su, Bing
AU  - Su B
FAU - Xu, Cheng
AU  - Xu C
FAU - Xu, Jianqin
AU  - Xu J
FAU - Ruan, Yuhua
AU  - Ruan Y
FAU - Shao, Yimin
AU  - Shao Y
FAU - Zheng, Dexian
AU  - Zheng D
LA  - eng
GR  - 1 U19 AI51915-02/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20131010
PL  - China
TA  - Sci China Life Sci
JT  - Science China. Life sciences
JID - 101529880
RN  - 0 (HLA-A3 Antigen)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - China
MH  - Cohort Studies
MH  - Disease Progression
MH  - Female
MH  - *Gene Frequency
MH  - HIV Infections/*genetics
MH  - *HIV-1
MH  - HLA-A3 Antigen/*genetics
MH  - Humans
MH  - Lymphocyte Count
MH  - Male
MH  - Middle Aged
MH  - Viral Load
MH  - Viremia/genetics
EDAT- 2013/10/12 06:00
MHDA- 2014/06/15 06:00
CRDT- 2013/10/12 06:00
PHST- 2012/03/19 00:00 [received]
PHST- 2012/09/03 00:00 [accepted]
PHST- 2013/10/12 06:00 [entrez]
PHST- 2013/10/12 06:00 [pubmed]
PHST- 2014/06/15 06:00 [medline]
AID - 10.1007/s11427-013-4555-4 [doi]
PST - ppublish
SO  - Sci China Life Sci. 2013 Nov;56(11):1014-9. doi: 10.1007/s11427-013-4555-4. Epub 
      2013 Oct 10.