PMID- 24115094
OWN - NLM
STAT- MEDLINE
DCOM- 20150124
LR  - 20220310
IS  - 1096-9071 (Electronic)
IS  - 0146-6615 (Linking)
VI  - 86
IP  - 7
DP  - 2014 Jul
TI  - Norovirus infection in immunocompromised children and children with 
      hospital-acquired acute gastroenteritis.
PG  - 1203-9
LID - 10.1002/jmv.23774 [doi]
AB  - Norovirus (NoV) is a leading cause of acute viral gastroenteritis among children, 
      yet its burden of disease among immunocompromised hosts and its role in hospital 
      acquired infections (HAI) is not well characterized. To determine the prevalence, 
      genotypes, and NoV loads among immunocompromised children and children with HAI, 
      residual stool samples, and clinical data were collected at two major pediatric 
      hospitals in metropolitan Atlanta from 92 children that were immunocompromised 
      and/or had a hospital acquired acute gastroenteritis. NoV was identified in 16.3% 
      (15/92) of all stool specimens; 23.4% (11/47) in immunocompromised only children, 
      and 13.3% (4/30) in children with HAI. All NoV positive cases were genogroup II 
      (GII), and GII.4 was the predominant strain followed by GII.3, GII.12, and 
      GII.13. The average NoV load for immunocompromised patients was 6.3 +/- 1.4 log 
      genome equivalent copies (GEC) per gram of stool compared to 5.8 +/- 1.1 log GEC 
      among patients with HAI. NoV infections are common among immunocompromised 
      children and children with hospital-acquired gastroenteritis, underscoring the 
      urgent need for rapid NoV detection system, and highlighting the importance of 
      strict hospital hygiene practices.
CI  - (c) 2013 Wiley Periodicals, Inc.
FAU - Munir, Naeemah
AU  - Munir N
AD  - Center for Global Safe Water, Rollins School of Public Health, Emory University, 
      Atlanta, Georgia.
FAU - Liu, Pengbo
AU  - Liu P
FAU - Gastanaduy, Paul
AU  - Gastanaduy P
FAU - Montes, Julia
AU  - Montes J
FAU - Shane, Andi
AU  - Shane A
FAU - Moe, Christine
AU  - Moe C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20130930
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
SB  - IM
MH  - Adolescent
MH  - Caliciviridae Infections/*epidemiology/virology
MH  - Child
MH  - Child, Preschool
MH  - Cross Infection/*epidemiology/virology
MH  - Feces/virology
MH  - Female
MH  - Gastroenteritis/*epidemiology/virology
MH  - Genotype
MH  - Georgia/epidemiology
MH  - Humans
MH  - Immunocompromised Host
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Norovirus/classification/genetics/*isolation & purification
MH  - Prevalence
MH  - Viral Load
OTO - NOTNLM
OT  - children
OT  - diarrhea
OT  - hospital-acquired infection
OT  - immunocompromised
OT  - norovirus
EDAT- 2013/10/12 06:00
MHDA- 2015/01/27 06:00
CRDT- 2013/10/12 06:00
PHST- 2013/08/09 00:00 [accepted]
PHST- 2013/10/12 06:00 [entrez]
PHST- 2013/10/12 06:00 [pubmed]
PHST- 2015/01/27 06:00 [medline]
AID - 10.1002/jmv.23774 [doi]
PST - ppublish
SO  - J Med Virol. 2014 Jul;86(7):1203-9. doi: 10.1002/jmv.23774. Epub 2013 Sep 30.