PMID- 24115338
OWN - NLM
STAT- MEDLINE
DCOM- 20140919
LR  - 20220316
IS  - 1531-8257 (Electronic)
IS  - 0885-3185 (Linking)
VI  - 29
IP  - 1
DP  - 2014 Jan
TI  - Herpes simplex encephalitis relapse with chorea is associated with autoantibodies 
      to N-Methyl-D-aspartate receptor or dopamine-2 receptor.
PG  - 117-22
LID - 10.1002/mds.25623 [doi]
AB  - BACKGROUND: Movement disorder relapses after herpes simplex virus 1 (HSV1) 
      encephalitis have been hypothesized to be secondary to postviral autoimmunity. 
      Recently, a proportion of patients with HSV1 encephalitis (HSE) were shown to 
      produce autoantibodies against N-methyl-D-aspartate receptor (NMDAR). METHODS: We 
      measured autoantibodies against NMDAR and dopamine-2 receptor (D2R) expressed at 
      the cell surface in the stored acute serum of 9 children with HSE, 3 of whom had 
      a relapsing course with chorea. RESULTS: The 3 patients with chorea had elevated 
      autoantibodies against NMDAR (n = 1), D2R (n = 1), or both (n = 1), whereas 
      patients without chorea were negative (n = 6). The prospectively identified 
      patient with chorea and NMDAR autoantibodies improved after early treatment with 
      steroids, intravenous immunoglobulin, and cyclophosphamide, with reduction in 
      serum NMDAR antibody titers. CONCLUSIONS: These autoantibody findings lend 
      support to the autoimmune hypothesis and the early use of immune suppression in 
      post-HSE chorea.
CI  - Copyright (c) 2013 Movement Disorder Society.
FAU - Mohammad, Shekeeb S
AU  - Mohammad SS
AD  - Neuroimmunology Group, Institute for Neuroscience and Muscle Research, Kids 
      Research Institute at the Children's Hospital at Westmead, University of Sydney, 
      Westmead, Australia; Department of Neurosciences, Royal Children's Hospital, 
      Brisbane, Australia; School of Medicine, University of Queensland, Brisbane, 
      Australia; TY Nelson Department of Neurology and Neurosurgery, Children's 
      Hospital at Westmead, Westmead, Australia.
FAU - Sinclair, Kate
AU  - Sinclair K
FAU - Pillai, Sekhar
AU  - Pillai S
FAU - Merheb, Vera
AU  - Merheb V
FAU - Aumann, Tim D
AU  - Aumann TD
FAU - Gill, Deepak
AU  - Gill D
FAU - Dale, Russell C
AU  - Dale RC
FAU - Brilot, Fabienne
AU  - Brilot F
LA  - eng
PT  - Journal Article
DEP - 20131001
PL  - United States
TA  - Mov Disord
JT  - Movement disorders : official journal of the Movement Disorder Society
JID - 8610688
RN  - 0 (Autoantibodies)
RN  - 0 (Receptors, Dopamine D2)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
SB  - IM
MH  - Autoantibodies/*blood
MH  - Child
MH  - Child, Preschool
MH  - Chorea/blood/complications/*immunology
MH  - Encephalitis, Herpes Simplex/blood/complications/*immunology
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Receptors, Dopamine D2/*immunology
MH  - Receptors, N-Methyl-D-Aspartate/*immunology
MH  - Recurrence
OTO - NOTNLM
OT  - NMDA receptor
OT  - autoantibody
OT  - chorea
OT  - dopamine-2 receptor
OT  - herpes simplex encephalitis
EDAT- 2013/10/12 06:00
MHDA- 2014/09/23 06:00
CRDT- 2013/10/12 06:00
PHST- 2013/02/06 00:00 [received]
PHST- 2013/05/31 00:00 [revised]
PHST- 2013/07/01 00:00 [accepted]
PHST- 2013/10/12 06:00 [entrez]
PHST- 2013/10/12 06:00 [pubmed]
PHST- 2014/09/23 06:00 [medline]
AID - 10.1002/mds.25623 [doi]
PST - ppublish
SO  - Mov Disord. 2014 Jan;29(1):117-22. doi: 10.1002/mds.25623. Epub 2013 Oct 1.