PMID- 24115947
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20220409
IS  - 1664-3224 (Print)
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 4
DP  - 2013 Oct 8
TI  - Interleukin-18 and IL-18 binding protein.
PG  - 289
LID - 10.3389/fimmu.2013.00289 [doi]
LID - 289
AB  - Interleukin-18 (IL-18) is a member of the IL-1 family of cytokines. Similar to 
      IL-1beta, IL-18 is synthesized as an inactive precursor requiring processing by 
      caspase-1 into an active cytokine but unlike IL-1beta, the IL-18 precursor is 
      constitutively present in nearly all cells in healthy humans and animals. The 
      activity of IL-18 is balanced by the presence of a high affinity, naturally 
      occurring IL-18 binding protein (IL-18BP). In humans, increased disease severity 
      can be associated with an imbalance of IL-18 to IL-18BP such that the levels of 
      free IL-18 are elevated in the circulation. Increasing number of studies have 
      expanded the role of IL-18 in mediating inflammation in animal models of disease 
      using the IL-18BP, IL-18-deficient mice, neutralization of IL-18, or deficiency 
      in the IL-18 receptor alpha chain. A role for IL-18 has been implicated in 
      several autoimmune diseases, myocardial function, emphysema, metabolic syndromes, 
      psoriasis, inflammatory bowel disease, hemophagocytic syndromes, macrophage 
      activation syndrome, sepsis, and acute kidney injury, although in some models of 
      disease, IL-18 is protective. IL-18 plays a major role in the production of 
      interferon-gamma from T-cells and natural killer cells. The IL-18BP has been used 
      safely in humans and clinical trials of IL-18BP as well as neutralizing 
      anti-IL-18 antibodies are in clinical trials. This review updates the biology of 
      IL-18 as well as its role in human disease.
FAU - Dinarello, Charles A
AU  - Dinarello CA
AD  - Department of Medicine, University of Colorado Denver , Aurora, CO , USA ; 
      Department of Medicine, University Medical Center Nijmegen , Nijmegen , 
      Netherlands.
FAU - Novick, Daniela
AU  - Novick D
FAU - Kim, Soohyun
AU  - Kim S
FAU - Kaplanski, Gilles
AU  - Kaplanski G
LA  - eng
GR  - R01 AI015614/AI/NIAID NIH HHS/United States
GR  - R01 AR045584/AR/NIAMS NIH HHS/United States
GR  - R56 AI015614/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20131008
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
PMC - PMC3792554
OTO - NOTNLM
OT  - autoimmune diseases
OT  - inflammasomes
OT  - inflammation
OT  - interleukin-1
OT  - macrophages
EDAT- 2013/10/12 06:00
MHDA- 2013/10/12 06:01
PMCR- 2013/01/01
CRDT- 2013/10/12 06:00
PHST- 2013/05/31 00:00 [received]
PHST- 2013/09/04 00:00 [accepted]
PHST- 2013/10/12 06:00 [entrez]
PHST- 2013/10/12 06:00 [pubmed]
PHST- 2013/10/12 06:01 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2013.00289 [doi]
PST - epublish
SO  - Front Immunol. 2013 Oct 8;4:289. doi: 10.3389/fimmu.2013.00289.