PMID- 24117825
OWN - NLM
STAT- MEDLINE
DCOM- 20140508
LR  - 20131014
IS  - 1600-065X (Electronic)
IS  - 0105-2896 (Linking)
VI  - 256
IP  - 1
DP  - 2013 Nov
TI  - Migration of dendritic cells: physical principles, molecular mechanisms, and 
      functional implications.
PG  - 240-54
LID - 10.1111/imr.12108 [doi]
AB  - Dendritic cells (DCs) constitute a complex cell population that resides in both 
      peripheral tissues and lymphoid organs. Their major function in tissues is to 
      patrol their environment in search of danger-associated antigens to transport to 
      lymph nodes and present to T lymphocytes. This process constitutes the first step 
      of the adaptive immune response and relies on specific DC properties, including a 
      high endocytic capacity as well as efficient motility in confined 
      three-dimensional environments. Although cell motility has been widely studied, 
      little is known on how the geometric characteristics of the environment influence 
      DC migration and function. In this review, we give an overview of the basic 
      physical principles and molecular mechanisms that control DC migration under 
      confinement and discuss how such mechanisms impact the environment-patrolling 
      capacity of DCs.
CI  - (c) 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Heuze, Melina L
AU  - Heuze ML
AD  - Inserm U932, Institut Curie, Paris, France.
FAU - Vargas, Pablo
AU  - Vargas P
FAU - Chabaud, Melanie
AU  - Chabaud M
FAU - Le Berre, Mael
AU  - Le Berre M
FAU - Liu, Yan-Jun
AU  - Liu YJ
FAU - Collin, Olivier
AU  - Collin O
FAU - Solanes, Paola
AU  - Solanes P
FAU - Voituriez, Raphael
AU  - Voituriez R
FAU - Piel, Matthieu
AU  - Piel M
FAU - Lennon-Dumenil, Ana-Maria
AU  - Lennon-Dumenil AM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Immunol Rev
JT  - Immunological reviews
JID - 7702118
RN  - 0 (Antigens)
SB  - IM
MH  - Animals
MH  - Antigens/immunology
MH  - Cell Movement/*immunology
MH  - Dendritic Cells/*physiology
MH  - Humans
OTO - NOTNLM
OT  - confinement
OT  - dendritic cells
OT  - migration
OT  - sampling
EDAT- 2013/10/15 06:00
MHDA- 2014/05/09 06:00
CRDT- 2013/10/15 06:00
PHST- 2013/10/15 06:00 [entrez]
PHST- 2013/10/15 06:00 [pubmed]
PHST- 2014/05/09 06:00 [medline]
AID - 10.1111/imr.12108 [doi]
PST - ppublish
SO  - Immunol Rev. 2013 Nov;256(1):240-54. doi: 10.1111/imr.12108.