PMID- 24118550
OWN - NLM
STAT- MEDLINE
DCOM- 20140825
LR  - 20221207
IS  - 1432-2277 (Electronic)
IS  - 0934-0874 (Linking)
VI  - 27
IP  - 2
DP  - 2014 Feb
TI  - Pretransplant identification of acute rejection risk following kidney 
      transplantation.
PG  - 129-38
LID - 10.1111/tri.12205 [doi]
AB  - Lack of an accepted definition for 'high immunological risk' hampers 
      individualization of immunosuppressive therapy after kidney transplantation. For 
      recipient-related risk factors for acute rejection, the most compelling evidence 
      points to younger age and African American ethnicity. Recipient gender, body 
      mass, previous transplantation, and concomitant infection or disease do not 
      appear to be influential. Deceased donation now has only a minor effect on 
      rejection risk, but older donor age remains a significant predictor. Conventional 
      immunological markers (human leukocyte antigen [HLA] mismatching, pretransplant 
      anti-HLA alloantibodies, and panel reactive antibodies) are being reassessed in 
      light of growing understanding about the role of donor-specific antibodies (DSA). 
      At the time of transplant, delayed graft function is one of the most clear-cut 
      risk factors for acute rejection. Extended cold ischemia time (>/= 24 h) may also 
      play a contributory role. While it is not yet possible to establish conclusively 
      the relative contribution of different risk factors for acute rejection after 
      kidney transplantation, the available data point to variables that should be 
      taken into account at the time of transplant. Together, these offer a realistic 
      basis for planning an appropriate immunosuppression regimen in individual 
      patients.
CI  - (c) 2013 Steunstichting ESOT. Published by John Wiley & Sons Ltd.
FAU - Lebranchu, Yvon
AU  - Lebranchu Y
AD  - Department of Nephrology and Clinical Immunology, EA 4245, CHRU Tours, Tours, 
      France.
FAU - Baan, Carla
AU  - Baan C
FAU - Biancone, Luigi
AU  - Biancone L
FAU - Legendre, Christophe
AU  - Legendre C
FAU - Morales, Jose Maria
AU  - Morales JM
FAU - Naesens, Maarten
AU  - Naesens M
FAU - Thomusch, Oliver
AU  - Thomusch O
FAU - Friend, Peter
AU  - Friend P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20131025
PL  - Switzerland
TA  - Transpl Int
JT  - Transplant international : official journal of the European Society for Organ 
      Transplantation
JID - 8908516
RN  - 0 (HLA Antigens)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Isoantibodies)
SB  - IM
MH  - Black or African American
MH  - Body Mass Index
MH  - Cold Temperature
MH  - Delayed Graft Function/immunology
MH  - Female
MH  - *Graft Rejection
MH  - Graft Survival
MH  - HLA Antigens/chemistry
MH  - Humans
MH  - Immunosuppression Therapy/*methods
MH  - Immunosuppressive Agents/therapeutic use
MH  - Ischemia
MH  - Isoantibodies/immunology
MH  - Kidney Transplantation/*methods
MH  - Male
MH  - Multivariate Analysis
MH  - Patient Compliance
MH  - Risk Factors
MH  - Time Factors
OTO - NOTNLM
OT  - acute rejection
OT  - donor
OT  - high risk
OT  - immunological
OT  - recipient
OT  - risk factors
EDAT- 2013/10/15 06:00
MHDA- 2014/08/26 06:00
CRDT- 2013/10/15 06:00
PHST- 2013/07/15 00:00 [received]
PHST- 2013/08/26 00:00 [revised]
PHST- 2013/10/02 00:00 [accepted]
PHST- 2013/10/15 06:00 [entrez]
PHST- 2013/10/15 06:00 [pubmed]
PHST- 2014/08/26 06:00 [medline]
AID - 10.1111/tri.12205 [doi]
PST - ppublish
SO  - Transpl Int. 2014 Feb;27(2):129-38. doi: 10.1111/tri.12205. Epub 2013 Oct 25.