PMID- 24118784
OWN - NLM
STAT- MEDLINE
DCOM- 20141014
LR  - 20220316
IS  - 1467-789X (Electronic)
IS  - 1467-7881 (Linking)
VI  - 15
IP  - 2
DP  - 2014 Feb
TI  - Effect of antioxidant vitamin supplementation on endothelial function in type 2 
      diabetes mellitus: a systematic review and meta-analysis of randomized controlled 
      trials.
PG  - 107-16
LID - 10.1111/obr.12114 [doi]
AB  - Controversy exists among trials assessing whether prolonged antioxidant vitamin 
      supplementation improves endothelial function in type 2 diabetes mellitus (T2DM) 
      subjects. The aim of this study was to systematically review and quantify the 
      effect of antioxidant vitamin supplementation on endothelial function in T2DM 
      subjects. MEDLINE, Cochrane, Scopus and Web of Science were searched up to 
      February 2013 for randomized controlled trials assessing the effect of 
      antioxidant vitamin E and/or C supplementation on endothelial function in T2DM 
      subjects. Ten randomized controlled trials comparing antioxidant 
      vitamin-supplemented and control groups (overall n = 296) met the inclusion 
      criteria. Post-intervention standardized mean difference (SMD) in endothelial 
      function did not reach statistical significance between groups (0.35; 95% 
      confidence interval = -0.17, 0.88; P = 0.18). In subgroup analysis, 
      post-intervention endothelial function was significantly improved by antioxidant 
      vitamin supplementation in T2DM subgroups with body mass index (BMI) </= 29.45 kg 
      m(-2) (SMD = 1.02; P < 0.05), but not in T2DM subgroups with BMI > 29.45 kg m(-2) 
      (SMD = -0.07; P = 0.70). In meta-regression, an inverse association was found 
      between BMI and post-intervention SMD in endothelial function (B = -0.024, P = 
      0.02). Prolonged antioxidant vitamin E and/or C supplementation could be 
      effective to improve endothelial function in non-obese T2DM subjects.
CI  - (c) 2013 The Authors. obesity reviews (c) 2013 International Association for the 
      Study of Obesity.
FAU - Montero, D
AU  - Montero D
AD  - Avignon University, LAPEC EA4278, Avignon, France.
FAU - Walther, G
AU  - Walther G
FAU - Stehouwer, C D A
AU  - Stehouwer CD
FAU - Houben, A J H M
AU  - Houben AJ
FAU - Beckman, J A
AU  - Beckman JA
FAU - Vinet, A
AU  - Vinet A
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20131007
PL  - England
TA  - Obes Rev
JT  - Obesity reviews : an official journal of the International Association for the 
      Study of Obesity
JID - 100897395
RN  - 0 (Antioxidants)
RN  - 0 (Blood Glucose)
RN  - 0 (Vitamins)
SB  - IM
MH  - Antioxidants/*administration & dosage/therapeutic use
MH  - Blood Glucose/drug effects
MH  - Diabetes Mellitus, Type 2/diet therapy/metabolism/*physiopathology
MH  - Dietary Supplements
MH  - Endothelium, Vascular/drug effects/*physiopathology
MH  - Humans
MH  - Oxidative Stress/*drug effects
MH  - Randomized Controlled Trials as Topic
MH  - Vitamins/*therapeutic use
OTO - NOTNLM
OT  - Antioxidant vitamin supplementation
OT  - body mass index
OT  - endothelial function
OT  - type 2 diabetes mellitus
EDAT- 2013/10/15 06:00
MHDA- 2014/10/15 06:00
CRDT- 2013/10/15 06:00
PHST- 2013/07/09 00:00 [received]
PHST- 2013/08/20 00:00 [revised]
PHST- 2013/09/02 00:00 [accepted]
PHST- 2013/10/15 06:00 [entrez]
PHST- 2013/10/15 06:00 [pubmed]
PHST- 2014/10/15 06:00 [medline]
AID - 10.1111/obr.12114 [doi]
PST - ppublish
SO  - Obes Rev. 2014 Feb;15(2):107-16. doi: 10.1111/obr.12114. Epub 2013 Oct 7.