PMID- 24119801
OWN - NLM
STAT- MEDLINE
DCOM- 20150911
LR  - 20181202
IS  - 1525-3198 (Electronic)
IS  - 0022-0302 (Linking)
VI  - 96
IP  - 12
DP  - 2013
TI  - Effects of grain, fructose, and histidine feeding on endotoxin and oxidative 
      stress measures in dairy heifers.
PG  - 7881-91
LID - S0022-0302(13)00695-4 [pii]
LID - 10.3168/jds.2013-7113 [doi]
AB  - Ruminal endotoxin and plasma oxidative stress biomarker concentrations were 
      studied in dairy heifers challenged with grain, fructose, and histidine in a 
      partial factorial study. Holstein-Friesian heifers [n=30; average body weight 
      (BW) of 359.3+/-47.3 kg] were randomly allocated to 5 treatment groups: (1) control 
      (no grain); (2) grain [crushed triticale at 1.2% of BW dry matter intake (DMI)]; 
      (3) grain (0.8% of BW DMI) + fructose (0.4% of BW DMI); (4) grain (1.2% of BW 
      DMI) + histidine (6g/head); and (5) grain (0.8% of BW DMI) + fructose (0.4% of BW 
      DMI) + histidine (6 g/head). Rumen samples were collected by stomach tube 5, 65, 
      115, 165, and 215 min after diet consumption and blood samples at 5 and 215 min 
      after consumption. Rumen fluid was analyzed for endotoxin concentrations. Plasma 
      was analyzed for concentrations of the following oxidative stress biomarkers: 
      reactive oxygen metabolites (dROM), biological antioxidant potential (BAP), 
      advanced oxidation protein products, and ceruloplasmin, and activity of 
      glutathione peroxidase. Dietary treatment had no effect on concentrations of 
      endotoxin or oxidative stress biomarkers. We observed no interactions of 
      treatment by time. Ruminal concentrations of endotoxin decreased during the 
      sampling period from 1.12x10(5) +/- 0.06 to 0.92x10(5) endotoxin units/mL +/- 0.05 (5 
      and 215 min after diet consumption, respectively). Concentrations of dROM and the 
      oxidative stress index (dROM/BAP x 100) increased over the sampling period, from 
      108.7 to 123.5 Carratelli units (Carr U), and from 4.1 to 4.8, respectively. 
      Ceruloplasmin concentrations markedly declined 5 min after the consumption of 
      diets, from 190 to 90 mg/L over the 215-min sampling period. Overall, a single 
      feeding challenge for dairy cattle with grain, fructose, and histidine, and 
      combinations thereof, may not be sufficient to induce marked changes in endotoxin 
      or oxidative stress biomarker concentrations.
CI  - Copyright (c) 2013 American Dairy Science Association. Published by Elsevier Inc. 
      All rights reserved.
FAU - Golder, H M
AU  - Golder HM
AD  - Dairy Science Group, Faculty of Veterinary Science, The University of Sydney, 
      Camden, New South Wales, Australia 2570; SBScibus, Camden, New South Wales, 
      Australia 2570. Electronic address: heleng@sbscibus.com.au.
FAU - Lean, I J
AU  - Lean IJ
FAU - Rabiee, A R
AU  - Rabiee AR
FAU - King, R
AU  - King R
FAU - Celi, P
AU  - Celi P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131011
PL  - United States
TA  - J Dairy Sci
JT  - Journal of dairy science
JID - 2985126R
RN  - 0 (Endotoxins)
RN  - 30237-26-4 (Fructose)
RN  - 4QD397987E (Histidine)
SB  - IM
MH  - Animal Feed/*analysis
MH  - Animal Nutritional Physiological Phenomena
MH  - Animals
MH  - Body Weight
MH  - Cattle/blood/*physiology
MH  - Diet/veterinary
MH  - Edible Grain/*metabolism
MH  - Endotoxins
MH  - Female
MH  - Fructose/*pharmacology
MH  - Histidine/*pharmacology
MH  - Oxidative Stress/*drug effects
MH  - Poaceae/metabolism
MH  - Rumen
OTO - NOTNLM
OT  - endotoxin
OT  - fructose
OT  - histidine
OT  - oxidative stress
EDAT- 2013/10/15 06:00
MHDA- 2015/09/12 06:00
CRDT- 2013/10/15 06:00
PHST- 2013/06/10 00:00 [received]
PHST- 2013/08/21 00:00 [accepted]
PHST- 2013/10/15 06:00 [entrez]
PHST- 2013/10/15 06:00 [pubmed]
PHST- 2015/09/12 06:00 [medline]
AID - S0022-0302(13)00695-4 [pii]
AID - 10.3168/jds.2013-7113 [doi]
PST - ppublish
SO  - J Dairy Sci. 2013;96(12):7881-91. doi: 10.3168/jds.2013-7113. Epub 2013 Oct 11.