PMID- 24121063
OWN - NLM
STAT- MEDLINE
DCOM- 20140801
LR  - 20131209
IS  - 1878-4216 (Electronic)
IS  - 0278-5846 (Linking)
VI  - 48
DP  - 2014 Jan 3
TI  - BDNF signaling is necessary for the antidepressant-like effect of naringenin.
PG  - 135-41
LID - S0278-5846(13)00218-2 [pii]
LID - 10.1016/j.pnpbp.2013.10.002 [doi]
AB  - Previous studies in our laboratory have demonstrated that naringenin produced 
      antidepressant-like action in tail suspension test (TST). However, the underlying 
      mechanisms involved in neurotrophin system by which naringenin works have not 
      been investigated. The present study extends earlier works on the role of 
      brain-derived neurotrophic factor (BDNF) in regulating the antidepressant-like 
      actions of naringenin in chronic unpredictable mild stress (CUMS). We showed that 
      a 21-day regimen with naringenin reversed the decreased sucrose preference in 
      sucrose preference test (SPT) and the prolonged first feeding latency in 
      novelty-suppressed feeding test (NSFT), without affecting home-cage feeding 
      consumption. In addition, we also found that naringenin promoted BDNF expression 
      in the hippocampus but not in the frontal cortex in both non-stressed and CUMS 
      mice. Moreover, the antidepressant-like effect of naringenin in SPT and NSFT 
      induced by naringenin administration were totally abolished by K252a, an 
      inhibitor of BDNF receptor tropomyosin-related kinase receptor B (TrkB). In 
      conclusion, our findings suggest that the antidepressant-like effect of 
      naringenin may be mediated, at least in part, by the activation of BDNF signaling 
      in the hippocampus.
CI  - (c) 2013.
FAU - Yi, Li-Tao
AU  - Yi LT
AD  - Department of Chemical and Pharmaceutical Engineering, College of Chemical 
      Engineering, Huaqiao University, Xiamen 361021, Fujian Province, PR China. 
      Electronic address: litao.yi@yahoo.com.
FAU - Liu, Bin-Bin
AU  - Liu BB
FAU - Li, Jing
AU  - Li J
FAU - Luo, Liu
AU  - Luo L
FAU - Liu, Qing
AU  - Liu Q
FAU - Geng, Di
AU  - Geng D
FAU - Tang, Yue
AU  - Tang Y
FAU - Xia, Yuan
AU  - Xia Y
FAU - Wu, Di
AU  - Wu D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131010
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Carbazoles)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Flavanones)
RN  - 0 (Indole Alkaloids)
RN  - 0 (Sweetening Agents)
RN  - 57-50-1 (Sucrose)
RN  - 97161-97-2 (staurosporine aglycone)
RN  - HN5425SBF2 (naringenin)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*therapeutic use
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Carbazoles/pharmacology
MH  - Disease Models, Animal
MH  - Enzyme Inhibitors/pharmacology
MH  - Exploratory Behavior/drug effects
MH  - Flavanones/*therapeutic use
MH  - Food Deprivation
MH  - Food Preferences/drug effects
MH  - Hippocampus/drug effects/metabolism
MH  - Indole Alkaloids/pharmacology
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Signal Transduction/*drug effects
MH  - Stress, Psychological/*drug therapy
MH  - Sucrose/administration & dosage
MH  - Sweetening Agents/administration & dosage
MH  - Up-Regulation/*drug effects
MH  - Water Deprivation
OTO - NOTNLM
OT  - BDNF
OT  - Brain-derived neurotrophic factor (BDNF)
OT  - CUMS
OT  - Chronic unpredictable mild stress
OT  - Depression
OT  - HPA
OT  - M-MLV
OT  - Moloney Murine Leukemia Virus
OT  - NSFT
OT  - Naringenin
OT  - SPT
OT  - TST
OT  - TrkB
OT  - brain-derived neurotrophic factor
OT  - chronic unpredictable mild stress
OT  - hypothalamic-pituitary-adrenal
OT  - novelty-suppressed feeding test
OT  - sucrose preference test
OT  - tail suspension test
OT  - tropomyosin-related kinase receptor B
EDAT- 2013/10/15 06:00
MHDA- 2014/08/02 06:00
CRDT- 2013/10/15 06:00
PHST- 2013/08/18 00:00 [received]
PHST- 2013/09/20 00:00 [revised]
PHST- 2013/10/01 00:00 [accepted]
PHST- 2013/10/15 06:00 [entrez]
PHST- 2013/10/15 06:00 [pubmed]
PHST- 2014/08/02 06:00 [medline]
AID - S0278-5846(13)00218-2 [pii]
AID - 10.1016/j.pnpbp.2013.10.002 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jan 3;48:135-41. doi: 
      10.1016/j.pnpbp.2013.10.002. Epub 2013 Oct 10.