PMID- 24121312
OWN - NLM
STAT- MEDLINE
DCOM- 20140625
LR  - 20161125
IS  - 1473-5628 (Electronic)
IS  - 0143-3636 (Linking)
VI  - 35
IP  - 1
DP  - 2014 Jan
TI  - Correlation of (18)F-fluoromisonidazole PET findings with HIF-1alpha and p53 
      expressions in head and neck cancer: comparison with (18)F-FDG PET.
PG  - 30-5
LID - 10.1097/MNM.0000000000000010 [doi]
AB  - OBJECTIVE: We evaluated tumor hypoxia using F-fluoromisonidazole (F-FMISO) PET in 
      relation to the expression of hypoxia-inducible factor-1alpha (HIF-1alpha) and p53 in 
      patients with head and neck cancer and compared the results with those obtained 
      using 2-deoxy-2-F-fluoro-D-glucose (F-FDG) PET. MATERIALS AND METHODS: A total of 
      28 tumors (23 primary tumors and five metastatic lymph nodes) from 24 patients 
      with newly diagnosed head and neck cancer were examined with F-FMISO PET and 
      F-FDG PET. The F-FMISO PET images were scaled to the venous blood concentration 
      of F-FMISO activity to produce tumor-to-blood (T/B) values. Hypoxia was defined 
      as a region with a T/B ratio greater than or equal to 1.2. The maximum T/B 
      (T/Bmax) and hypoxic volumes were calculated by region-of-interest analysis. For 
      F-FDG PET, the maximum standardized uptake value (SUVmax) and hypermetabolic 
      volume were calculated by region-of-interest analysis. The expressions of HIF-1alpha 
      and p53 using immunohistochemistry were estimated in tumor tissue samples. 
      RESULTS: A weak correlation was observed between hypoxic volume and T/Bmax 
      (r=0.53, P=0.003) on using F-FMISO PET and between hypermetabolic volume and 
      SUVmax (r=0.38, P=0.046) on using F-FDG PET. The hypoxic volume using F-FMISO PET 
      and hypermetabolic volume using F-FDG PET also showed a weak correlation (r=0.44, 
      P=0.020). The values of F-FMISO hypoxic volume showed a weak correlation with 
      HIF-1alpha (r=0.40, P=0.037) and p53 (r=0.47, P=0.012) obtained on 
      immunohistochemical examination. CONCLUSION: This study demonstrates a weak 
      correlation between hypoxic volume measured by F-FMISO PET and expressions of 
      HIF-1alpha and p53 in head and neck cancer.
FAU - Norikane, Takashi
AU  - Norikane T
AD  - Departments of aRadiology bMedical Physics cDiagnostic Pathology dOral and 
      Maxillofacial Surgery eOtolaryngology, Faculty of Medicine, Kagawa University, 
      Kagawa, Japan.
FAU - Yamamoto, Yuka
AU  - Yamamoto Y
FAU - Maeda, Yukito
AU  - Maeda Y
FAU - Kudomi, Nobuyuki
AU  - Kudomi N
FAU - Matsunaga, Toru
AU  - Matsunaga T
FAU - Haba, Reiji
AU  - Haba R
FAU - Iwasaki, Akinori
AU  - Iwasaki A
FAU - Hoshikawa, Hiroshi
AU  - Hoshikawa H
FAU - Nishiyama, Yoshihiro
AU  - Nishiyama Y
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Nucl Med Commun
JT  - Nuclear medicine communications
JID - 8201017
RN  - 0 (HIF1A protein, human)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Tumor Suppressor Protein p53)
RN  - 082285VIDF (fluoromisonidazole)
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
RN  - 8FE7LTN8XE (Misonidazole)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biological Transport
MH  - Female
MH  - *Fluorodeoxyglucose F18/metabolism
MH  - *Gene Expression Regulation, Neoplastic
MH  - Head and Neck Neoplasms/*diagnostic imaging/metabolism
MH  - Humans
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Misonidazole/*analogs & derivatives/metabolism
MH  - *Positron-Emission Tomography
MH  - Tumor Suppressor Protein p53/*metabolism
EDAT- 2013/10/15 06:00
MHDA- 2014/06/26 06:00
CRDT- 2013/10/15 06:00
PHST- 2013/10/15 06:00 [entrez]
PHST- 2013/10/15 06:00 [pubmed]
PHST- 2014/06/26 06:00 [medline]
AID - 10.1097/MNM.0000000000000010 [doi]
PST - ppublish
SO  - Nucl Med Commun. 2014 Jan;35(1):30-5. doi: 10.1097/MNM.0000000000000010.