PMID- 24122191
OWN - NLM
STAT- MEDLINE
DCOM- 20131029
LR  - 20141212
IS  - 1833-3516 (Print)
IS  - 1833-3516 (Linking)
VI  - 43
IP  - 3
DP  - 2013 Sep
TI  - Characterization of early thermal burns and the effects of hyperbaric oxygen 
      treatment: a pilot study.
PG  - 157-61
AB  - BACKGROUND AND AIMS: Studies investigating hyperbaric oxygen treatment (HBOT) to 
      improve outcome in burns have been inconclusive. In this study, we aimed to 
      characterize early thermal burns injury in adult patients with < 40% total body 
      surface area (TBSA) and to determine the effects of HBOT administered within 24 h 
      to 48 h of a burn injury. METHODS: Seventeen subjects were randomized into 
      control (n = 9) and HBOT treatment (n = 8) arms. Burn depth, measured by laser 
      Doppler imaging (LDI) and histologically, white blood cell (WBC) count and plasma 
      cytokine inflammatory markers were assessed at 24 h (pre HBOT) and 48 h (post 
      HBOT) post burn, as were immunohistochemistry and microbiology of burns tissue 
      samples at 48 h post burn. RESULTS: WBC count and serum interleukin (IL)-1beta, 
      IL-4, IL-6, IL-10 and interferon-gamma were significantly elevated 24 h after burn, 
      but no significant changes in any of these parameters were found with HBOT. HBOT 
      had no significant effect on burn depth. Two HBOT patients and four control 
      patients developed positive bacterial cultures. CONCLUSIONS: Slower than 
      anticipated recruitment resulted in considerably fewer patients than planned 
      being studied. Inflammatory markers were significantly increased at 24 h in 
      patients with < 40% TBSA burn. Early HBOT had no apparent effects on any of the 
      parameters measured in this small pilot study. HBOT may possibly have a 
      broad-spectrum antimicrobial effect worthy of further study. We report our 
      methodology in detail as a possible model for future burns studies.
FAU - Chong, Si Jack
AU  - Chong SJ
AD  - Navy Medical Services, Republic of Singapore Navy and Department of Plastic, 
      Reconstructive and Aesthetic Surgery Singapore General Hospital Outram Road, 
      Singapore 169608 Phone: +65-9146-7592, E-mail: chong_si_jack@hotmail.com.
FAU - Kan, Enci Mary
AU  - Kan EM
FAU - Song, Colin
AU  - Song C
FAU - Soh, Chai Rick
AU  - Soh CR
FAU - Lu, Jia
AU  - Lu J
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Diving Hyperb Med
JT  - Diving and hyperbaric medicine
JID - 101282742
RN  - 0 (Interleukins)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Adult
MH  - Blood Cell Count
MH  - Body Surface Area
MH  - Burns/blood/pathology/*therapy
MH  - Female
MH  - Humans
MH  - Hyperbaric Oxygenation/*methods
MH  - Interferon-gamma/blood
MH  - Interleukins/blood
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - Prospective Studies
MH  - Young Adult
OTO - NOTNLM
OT  - Burns
OT  - Doppler
OT  - bacteriology
OT  - hyperbaric oxygen therapy
OT  - inflammation
EDAT- 2013/10/15 06:00
MHDA- 2013/10/30 06:00
CRDT- 2013/10/15 06:00
PHST- 2012/11/07 00:00 [received]
PHST- 2013/06/16 00:00 [accepted]
PHST- 2013/10/15 06:00 [entrez]
PHST- 2013/10/15 06:00 [pubmed]
PHST- 2013/10/30 06:00 [medline]
PST - ppublish
SO  - Diving Hyperb Med. 2013 Sep;43(3):157-61.