PMID- 24122403
OWN - NLM
STAT- MEDLINE
DCOM- 20140806
LR  - 20231104
IS  - 1433-7339 (Electronic)
IS  - 0941-4355 (Print)
IS  - 0941-4355 (Linking)
VI  - 22
IP  - 2
DP  - 2014 Feb
TI  - Effect of general symptom level, specific adverse events, treatment patterns, and 
      patient characteristics on health-related quality of life in patients with 
      multiple myeloma: results of a European, multicenter cohort study.
PG  - 417-26
AB  - PURPOSE: Novel multiple myeloma (MM) therapies have increased patient longevity 
      but are often associated with notable symptom burden. This study quantified the 
      effect of general symptom level, specific symptoms, and treatment-related adverse 
      events (AEs) on MM patients' health-related quality of life (HRQoL). METHODS: The 
      European Organization for Research and Treatment of Cancer (EORTC) generic cancer 
      questionnaire (Quality of Life Questionnaire Core 30) and MM-specific 
      questionnaire (QLQ-MY20) were used in this study to assess patients' HRQoL. Data 
      were collected on sociodemographics, disease and treatment history, and the 
      presence/severity of MM-related symptoms or treatment-related AEs from patients 
      with MM in UK and German centers. Multiple regression analyses were conducted. 
      RESULTS: Of 154 patients (63 % male; mean age, 66.4 years; mean time since 
      diagnosis, 3.7 years; 52 % currently on treatment; and 43 % with >/= 1 prior MM 
      therapy), 25, 32, 31, and 11 % were severely symptomatic, moderately symptomatic, 
      mildly symptomatic, and asymptomatic, respectively. Fatigue (59 %), bone pain (51 
      %), sleepiness (36 %), hypoesthesia or paresthesia (33 %), and muscle cramps (31 
      %) were most commonly reported. Moderate and severe general symptom levels, bone 
      symptoms, depression, and mental status changes were identified as strong 
      determinants of HRQoL. CONCLUSIONS: Severity, type of disease symptoms, and 
      treatment related AEs are important HRQoL determinants in patients with MM, 
      allowing for targeted treatment.
FAU - Jordan, Karin
AU  - Jordan K
FAU - Proskorovsky, Irina
AU  - Proskorovsky I
FAU - Lewis, Philip
AU  - Lewis P
FAU - Ishak, Jack
AU  - Ishak J
FAU - Payne, Krista
AU  - Payne K
FAU - Lordan, Noreen
AU  - Lordan N
FAU - Kyriakou, Charalampia
AU  - Kyriakou C
FAU - Williams, Cathy D
AU  - Williams CD
FAU - Peters, Sarah
AU  - Peters S
FAU - Davies, Faith E
AU  - Davies FE
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Support Care Cancer
JT  - Supportive care in cancer : official journal of the Multinational Association of 
      Supportive Care in Cancer
JID - 9302957
SB  - IM
MH  - Aged
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Depression/etiology
MH  - Female
MH  - Germany
MH  - Humans
MH  - Male
MH  - Multiple Myeloma/*physiopathology/psychology/*therapy
MH  - Quality of Life
MH  - Socioeconomic Factors
MH  - Surveys and Questionnaires
MH  - United Kingdom
PMC - PMC3882558
EDAT- 2013/10/15 06:00
MHDA- 2014/08/07 06:00
PMCR- 2013/10/13
CRDT- 2013/10/15 06:00
PHST- 2013/03/07 00:00 [received]
PHST- 2013/09/17 00:00 [accepted]
PHST- 2013/10/15 06:00 [entrez]
PHST- 2013/10/15 06:00 [pubmed]
PHST- 2014/08/07 06:00 [medline]
PHST- 2013/10/13 00:00 [pmc-release]
AID - 1991 [pii]
AID - 10.1007/s00520-013-1991-4 [doi]
PST - ppublish
SO  - Support Care Cancer. 2014 Feb;22(2):417-26. doi: 10.1007/s00520-013-1991-4.