PMID- 24122604
OWN - NLM
STAT- MEDLINE
DCOM- 20140925
LR  - 20220318
IS  - 1179-187X (Electronic)
IS  - 1175-3277 (Linking)
VI  - 14
IP  - 1
DP  - 2014 Feb
TI  - Vitamin D and the cardiovascular system: an overview of the recent literature.
PG  - 1-14
AB  - Since the discovery that the enzyme catalyzing the synthesis of the most active 
      natural vitamin D metabolite(calcitriol) and the vitamin D-specific receptor 
      (VDR)were expressed in a wide range of tissues and organs, not only involved in 
      the mineral metabolism (MM), there has been increasing interest on the putative 
      'non classical' roles of vitamin D metabolites, particularly on their possible 
      effects on the cardiovascular (CV) system. These hypothetical CV effects of 
      vitamin D gained particular interesting the nephrology field, given the high 
      prevalence of CV disease in patients affected by either acute or chronic kidney 
      diseases. However, notwithstanding a huge amount of experimental data suggesting 
      a possible protective role of vitamin D on the CV system, the conclusions of two 
      recent meta-analyses from the Cochrane group and a recent statement from the 
      Institute of Medicine, based on a complete revision of the available data, 
      concluded that there is no clear evidence for a role of vitamin D other than that 
      strictly associated with bone health. However, a continuous and increasing flow 
      of new studies still continues to add information on this topic. In the present 
      review, we have tried to critically address the data added on this topicin the 
      last 2 years, considering separately the experimental,observational, and 
      intervention studies that have appeared in PubMed in the last 2 years, discussing 
      the data providing proof, pro or contra, the involvement of vitamin D in CV 
      disease, both in the absence or presence of kidney function impairment.
FAU - Messa, Piergiorgio
AU  - Messa P
FAU - Curreri, Manuela
AU  - Curreri M
FAU - Regalia, Anna
AU  - Regalia A
FAU - Alfieri, Carlo Maria
AU  - Alfieri CM
LA  - eng
PT  - Journal Article
PT  - Review
PL  - New Zealand
TA  - Am J Cardiovasc Drugs
JT  - American journal of cardiovascular drugs : drugs, devices, and other 
      interventions
JID - 100967755
RN  - 0 (Receptors, Calcitriol)
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - Animals
MH  - Cardiovascular Diseases/*physiopathology
MH  - Cardiovascular System/*metabolism/physiopathology
MH  - Humans
MH  - Receptors, Calcitriol/metabolism
MH  - Renal Insufficiency/physiopathology
MH  - Vitamin D/*metabolism
EDAT- 2013/10/15 06:00
MHDA- 2014/09/26 06:00
CRDT- 2013/10/15 06:00
PHST- 2013/10/15 06:00 [entrez]
PHST- 2013/10/15 06:00 [pubmed]
PHST- 2014/09/26 06:00 [medline]
AID - 10.1007/s40256-013-0047-y [doi]
PST - ppublish
SO  - Am J Cardiovasc Drugs. 2014 Feb;14(1):1-14. doi: 10.1007/s40256-013-0047-y.